CD2-associated protein: Difference between revisions

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<StructureSection load='2j6f' size='350' side='right' caption='Structure of human CD2AP SH3 domain 1 complex with E3 ubiquitin ligase peptide (pink) (PDB entry [[2j6f]])' scene=''>
<StructureSection load='2j6o' size='350' side='right' caption='Structure of human CD2AP SH3 domain 1 (green) complex with E3 ubiquitin ligase peptide (magenta) (PDB entry [[2j6o]])' scene='56/569738/Cv/1'>


'''CD2-associated protein''' (CD2AP) called also '''CMS''', is a scaffolding protein which regulates actin cytoskeleton.  CD2AP SH3 domain interacts with actin and a variety of membrane proteins.  CD2AP contains in its N-terminal 3 SH3 domains followed by a proline-rich region.
__TOC__


==3D structures of CD2-associated protein==
== Function ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
'''CD2-associated protein''' (CD2AP) called also '''CMS''', is a scaffolding protein which regulates actin cytoskeleton.  CD2AP SH3 domain interacts with actin and a variety of membrane proteins.  CD2AP contains in its N-terminal 3 SH3 domains followed by a proline-rich region.<ref>PMID:12354621</ref><ref>PMID:17020880</ref>


===CD2AP SH3 domain 1===
== Disease ==


[[2j6k]] – hCD2AP – human <br />
Haploinsufficiency of CD2AP is associated with susceptibility of glomerular disease
[[2krm]] – mCD2AP – mouse - NMR <br />
[[2j6f]] – hCD2AP + E3 ubiquitin protein ligase peptide  <br />
[[2j6o]], [[2j7i]] – hCD2AP + CD2 peptide  <br />


===CD2AP SH3 domain 2===
==3D structures of CD2-associated protein==
 
[[CD2-associated protein 3D structures]]
[[2fei]] – hCD2AP – NMR<br />
[[2krn]] – mCD2AP– NMR<br />
[[3u23]] - hCD2AP + RIN3 proline-rich peptide<br />
 
===CD2AP SH3 domain 3===
 
[[2jte]], [[2kro]] – mCD2AP - NMR<br />
[[2lz6]] – hCD2AP + ubiquitin - NMR<br />


===CD2AP proline-rich domain===
</StructureSection>


[[3lk4]], [[3aa6]] – hCD2AP + CapZ<br />
== References ==
<references/>
[[Category: Topic Page]]

Latest revision as of 09:06, 30 April 2019

Structure of human CD2AP SH3 domain 1 (green) complex with E3 ubiquitin ligase peptide (magenta) (PDB entry 2j6o)

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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