4lh6: Difference between revisions

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{{STRUCTURE_4lh6|  PDB=4lh6  |  SCENE=  }}
===Crystal structure of a LigA inhibitor===
{{ABSTRACT_PUBMED_24287382}}


==Function==
==Crystal structure of a LigA inhibitor==
[[http://www.uniprot.org/uniprot/DNLJ_ENTFA DNLJ_ENTFA]] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).  
<StructureSection load='4lh6' size='340' side='right'caption='[[4lh6]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4lh6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LH6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1X7:4-AMINO-2-BROMOTHIENO[3,2-C]PYRIDINE-7-CARBOXAMIDE'>1X7</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lh6 OCA], [https://pdbe.org/4lh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lh6 RCSB], [https://www.ebi.ac.uk/pdbsum/4lh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lh6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DNLJ_ENTFA DNLJ_ENTFA] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).


==About this Structure==
==See Also==
[[4lh6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LH6 OCA].
*[[DNA ligase 3D structures|DNA ligase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:024287382</ref><references group="xtra"/><references/>
[[Category: Enterococcus faecalis V583]]
[[Category: Benenato, K.]]
[[Category: Large Structures]]
[[Category: Boriack-Sjodin, P A.]]
[[Category: Benenato K]]
[[Category: Davis, H.]]
[[Category: Boriack-Sjodin PA]]
[[Category: Gao, N.]]
[[Category: Davis H]]
[[Category: Jahic, H.]]
[[Category: Gao N]]
[[Category: Mcguire, H M.]]
[[Category: Jahic H]]
[[Category: Prince, D B.]]
[[Category: Mcguire HM]]
[[Category: Stokes, S S.]]
[[Category: Prince DB]]
[[Category: Wang, H.]]
[[Category: Stokes SS]]
[[Category: Ligase-ligase inhibitor complex]]
[[Category: Wang H]]
[[Category: Protein-inhibitor complex]]
Retrieved from "https://proteopedia.org/4lh6"