Adapter molecule crk: Difference between revisions

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New page: <StructureSection load='1cka' size='350' side='right' caption='Structure of mouse Crk N terminal SH3 domain complex with proline-rich peptide (PDB entry 1cka)' scene=''> '''Adapt...
 
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<StructureSection load='1cka' size='350' side='right' caption='Structure of mouse Crk N terminal SH3 domain (magenta) complex with proline-rich peptide (green) (PDB entry [[1cka]])' scene='57/573988/Cv/1'>


<StructureSection load='1cka' size='350' side='right' caption='Structure of mouse Crk N terminal SH3 domain complex with proline-rich peptide (PDB entry [[1cka]])' scene=''>
== Function ==
      
      
'''Adapter molecule crk''' (Crk) ('''C'''T10 '''R'''egulatior of '''K'''inase) is a proto-oncogene which participates in the Reelin signaling cascade.  Crk binds to several tyrosine-phosphorylated proteins. Crk domains include several SH2 and SH3 domains.
'''Adapter molecule crk''' (Crk) ('''C'''T10 '''R'''egulatior of '''K'''inase) or '''p38''' is a proto-oncogene which participates in the Reelin signaling cascade.  Crk binds to several tyrosine-phosphorylated proteins.<ref>PMID:12086608</ref> See also [[SRC]] and [[Oncogenes & Tumor Suppressor Genes]].


==3D structures of adpter molecule crk==
== Structural highlights ==


[[1m30]], [[1m3a]], [[1m3b]], [[1m3c]] – mCrk N terminal SH3 (mutant) – mouse - NMR<br />
Crk domains include several N-terminal SH2 and C-terminal SH3 domains. <scene name='57/573988/Cv/4'>Mouse Crk N terminal SH3 domain complex with proline-rich peptide</scene> ([[1cka]])<ref>PMID:7735837</ref> is shown.
[[2ggr]] – mCrk C terminal SH3 - NMR<br />
 
[[2l3p]], [[2l3q]], [[2l3s]] – Crk residues 220-297 – chicken – NMR<br />
==3D structures of adapter molecule crk==
[[1cka]], [[1ckb]] – mCrk N terminal SH3 + proline-rich peptide<br />
[[Adapter molecule crk 3D structures]]
[[1b07]] – mCrk N terminal SH3 + SH3 peptoid inhibitor<br />
 
[[1ju5]] – hCrk SH2 + phosphopeptide + Abl SH3 - human<br />
</StructureSection>
 
 
== References ==
<references/>
[[Category:Topic Page]]
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