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{{STRUCTURE_4ndy|  PDB=4ndy  |  SCENE=  }}
===Human MHF1-MHF2 DNA complex===
{{ABSTRACT_PUBMED_24390579}}


==Function==
==Human MHF1-MHF2 DNA complex==
[[http://www.uniprot.org/uniprot/CENPX_HUMAN CENPX_HUMAN]] DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation.<ref>PMID:19620631</ref> <ref>PMID:22814378</ref> [REFERENCE:6] [[http://www.uniprot.org/uniprot/CENPS_HUMAN CENPS_HUMAN]] DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.<ref>PMID:19620631</ref> <ref>PMID:22814378</ref> [REFERENCE:8]  
<StructureSection load='4ndy' size='340' side='right'caption='[[4ndy]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ndy]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NDY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NDY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 6.999&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ndy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ndy OCA], [https://pdbe.org/4ndy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ndy RCSB], [https://www.ebi.ac.uk/pdbsum/4ndy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ndy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CENPS_HUMAN CENPS_HUMAN] DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.<ref>PMID:19620631</ref> <ref>PMID:22814378</ref> [REFERENCE:8]


==About this Structure==
==See Also==
[[4ndy]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NDY OCA].
*[[Centromere protein 3D structure|Centromere protein 3D structure]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:024390579</ref><references group="xtra"/><references/>
__TOC__
[[Category: Sachpatzidis, A.]]
</StructureSection>
[[Category: Saro, D.]]
[[Category: Homo sapiens]]
[[Category: Sung, P.]]
[[Category: Large Structures]]
[[Category: Xiong, Y.]]
[[Category: Synthetic construct]]
[[Category: Zhao, Q.]]
[[Category: Sachpatzidis A]]
[[Category: Centromere construction]]
[[Category: Saro D]]
[[Category: Dna binding protein-dna complex]]
[[Category: Sung P]]
[[Category: Dna repair]]
[[Category: Xiong Y]]
[[Category: Fancm]]
[[Category: Zhao Q]]
[[Category: Fanconi anemia]]
[[Category: Genome maintenance]]
[[Category: Histone fold]]
[[Category: Nucleus]]

Latest revision as of 12:32, 1 March 2024

Human MHF1-MHF2 DNA complex

4ndy, resolution 7.00Å

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