2mgn: Difference between revisions
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== | ==Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3== | ||
[[2mgn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MGN OCA]. | <StructureSection load='2mgn' size='340' side='right'caption='[[2mgn]]' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2mgn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MGN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PQ3:N2,N9-BIS(1-METHYLQUINOLIN-3-YL)-1,10-PHENANTHROLINE-2,9-DICARBOXAMIDE'>PQ3</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mgn OCA], [https://pdbe.org/2mgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mgn RCSB], [https://www.ebi.ac.uk/pdbsum/2mgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mgn ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Phen-DC3 is a highly promising compound that specifically targets G-quadruplexes, with potent biological effects observed in vivo. We used NMR spectroscopy to solve the structure of the complex formed between Phen-DC3 and an intramolecular G-quadruplex derived from the c-myc promoter. Structural information revealed that Phen-DC3 interacts with the quadruplex through extensive pi-stacking with guanine bases of the top G-tetrad. On the basis of our structure, modifications are proposed for the development of this compound for selective targeting of a specific G-quadruplex conformation. | |||
Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3.,Chung WJ, Heddi B, Hamon F, Teulade-Fichou MP, Phan AT Angew Chem Int Ed Engl. 2014 Jan 20;53(4):999-1002. doi: 10.1002/anie.201308063. , Epub 2013 Dec 16. PMID:24356977<ref>PMID:24356977</ref> | |||
<ref | |||
[[Category: Chung | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
[[Category: Hamon | </div> | ||
[[Category: Heddi | <div class="pdbe-citations 2mgn" style="background-color:#fffaf0;"></div> | ||
[[Category: Phan | == References == | ||
[[Category: Teulade-Fichou | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Chung WJ]] | |||
[[Category: Hamon F]] | |||
[[Category: Heddi B]] | |||
[[Category: Phan AT]] | |||
[[Category: Teulade-Fichou MP]] | |||
Latest revision as of 06:05, 15 May 2024
Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3
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