4mgr: Difference between revisions
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== | ==The crystal structure of Bacillus subtilis GabR, an autorepressor and PLP- and GABA-dependent transcriptional activator of gabT== | ||
[[http://www.uniprot.org/uniprot/GABR_BACSU GABR_BACSU | <StructureSection load='4mgr' size='340' side='right'caption='[[4mgr]], [[Resolution|resolution]] 2.55Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4mgr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MGR FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mgr OCA], [https://pdbe.org/4mgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mgr RCSB], [https://www.ebi.ac.uk/pdbsum/4mgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mgr ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GABR_BACSU GABR_BACSU] Activates the transcription of the gabTD operon. Is also a repressor of its own expression, both in the presence and absence of GABA. Binds specifically to the DNA region overlapping the -35 region of the gabT promoter and the -10 and +1 regions of the gabR promoter. Principally regulates the utilization of gamma-aminobutyrate.<ref>PMID:12123465</ref> <ref>PMID:15223311</ref> | |||
== | ==See Also== | ||
[[ | *[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]] | ||
== References == | |||
== | <references/> | ||
__TOC__ | |||
[[Category: Bacillus | </StructureSection> | ||
[[Category: Bach | [[Category: Bacillus subtilis]] | ||
[[Category: Belitsky | [[Category: Large Structures]] | ||
[[Category: Edayathumangalam | [[Category: Bach A]] | ||
[[Category: Garcia | [[Category: Belitsky BR]] | ||
[[Category: Hoang | [[Category: Edayathumangalam R]] | ||
[[Category: Kreinbring | [[Category: Garcia R]] | ||
[[Category: Liao | [[Category: Hoang QQ]] | ||
[[Category: Liu | [[Category: Kreinbring CA]] | ||
[[Category: Petsko | [[Category: Liao J]] | ||
[[Category: Ringe | [[Category: Liu D]] | ||
[[Category: Stone | [[Category: Petsko GA]] | ||
[[Category: Terwilliger | [[Category: Ringe D]] | ||
[[Category: Wang | [[Category: Stone T]] | ||
[[Category: Wang | [[Category: Terwilliger T]] | ||
[[Category: Wu | [[Category: Wang W]] | ||
[[Category: Wang Y]] | |||
[[Category: Wu R]] | |||
Latest revision as of 12:26, 1 March 2024
The crystal structure of Bacillus subtilis GabR, an autorepressor and PLP- and GABA-dependent transcriptional activator of gabT
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