4omh: Difference between revisions
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New page: '''Unreleased structure''' The entry 4omh is ON HOLD Authors: Janke, R., Goerner, C., Hirte, M., Brueck, T., Loll, B. Description: Crystal structure of a diterpene cyclase |
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==Crystal structure of the bacterial diterpene cyclase COTB2 variant F149L== | |||
<StructureSection load='4omh' size='340' side='right'caption='[[4omh]], [[Resolution|resolution]] 1.64Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4omh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_melanosporofaciens Streptomyces melanosporofaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OMH FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4omh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4omh OCA], [https://pdbe.org/4omh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4omh RCSB], [https://www.ebi.ac.uk/pdbsum/4omh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4omh ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/COTB2_STRMJ COTB2_STRMJ] Catalyzes the cyclization of the linear isoprenoid intermediate geranylgeranyl diphosphate to tricycclic cyclooctat-9-en-7-ol in the cyclooctatin biosynthesis pathway. Cyclooctatin is a potent inhibitor of lysophospholipase.<ref>PMID:19635410</ref> <ref>PMID:24914964</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Streptomyces melanosporofaciens]] | |||
[[Category: Brueck T]] | |||
[[Category: Goerner C]] | |||
[[Category: Hirte M]] | |||
[[Category: Janke R]] | |||
[[Category: Loll B]] | |||
Latest revision as of 12:40, 1 March 2024
Crystal structure of the bacterial diterpene cyclase COTB2 variant F149L
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