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{{STRUCTURE_4chc|  PDB=4chc  |  SCENE=  }}
===Crystal structure of the N-terminal domain of the PA subunit of Thogoto virus polymerase (form 2)===
{{ABSTRACT_PUBMED_24454773}}


==Function==
==Crystal structure of the N-terminal domain of the PA subunit of Thogoto virus polymerase (form 2)==
[[http://www.uniprot.org/uniprot/PA_THOGV PA_THOGV]] Initiates transcription by a unique cap-stealing mechanism that involves the cleavage of only the m(7)GpppAm structure from cellular hnRNAs.  
<StructureSection load='4chc' size='340' side='right'caption='[[4chc]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4chc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Thogoto_thogotovirus Thogoto thogotovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CHC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.77&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4chc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chc OCA], [https://pdbe.org/4chc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4chc RCSB], [https://www.ebi.ac.uk/pdbsum/4chc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4chc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PA_THOGV PA_THOGV] Initiates transcription by a unique cap-stealing mechanism that involves the cleavage of only the m(7)GpppAm structure from cellular hnRNAs.


==About this Structure==
==See Also==
[[4chc]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHC OCA].
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:024454773</ref><references group="xtra"/><references/>
[[Category: Large Structures]]
[[Category: Bouvier, D.]]
[[Category: Thogoto thogotovirus]]
[[Category: Crepin, T.]]
[[Category: Bouvier D]]
[[Category: Cusack, S.]]
[[Category: Crepin T]]
[[Category: Guilligay, D.]]
[[Category: Cusack S]]
[[Category: Kadlec, J.]]
[[Category: Guilligay D]]
[[Category: Kochs, G.]]
[[Category: Kadlec J]]
[[Category: Lunardi, T.]]
[[Category: Kochs G]]
[[Category: Ruigrok, R W.H.]]
[[Category: Lunardi T]]
[[Category: Viral protein]]
[[Category: Ruigrok RWH]]

Latest revision as of 07:18, 1 May 2024

Crystal structure of the N-terminal domain of the PA subunit of Thogoto virus polymerase (form 2)

4chc, resolution 2.77Å

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