CD8: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
Michal Harel (talk | contribs)
32,820 edits
No edit summary
Michal Harel (talk | contribs)
32,820 edits
No edit summary
 
(11 intermediate revisions by 2 users not shown)
Line 1: Line 1:
<StructureSection load='3b9k' size='350' side='right' caption='Structure of CD8α (grey and magenta) and CD8β (green and cyan) complex with antibody heavy chain (aqua and pink) and light chain (red and yellow) (PDB entry [[3b9k]])' scene=''>
<StructureSection load='3b9k' size='350' side='right' caption='Structure of CD8α (magenta) and CD8β (green) complex with antibody heavy chain (cyan) and light chain (salmon) (PDB entry [[3b9k]])' scene='55/551462/Cv/1'>
 
 
== Function ==
    
    
'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor.  CD8 binds to class I MHC protein.  CD8 exists as 2 isoforms: α and β.  CD8 forms a dimer of CD8α and CD8β.  The extracellular domain of CD8 has immunoglobulin variable-like conformation.  This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.
'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor.  CD8 binds to class I MHC protein.  CD8 exists as 2 isoforms: α and β.  CD8 forms a dimer of CD8α and CD8β.  The extracellular domain of CD8 has immunoglobulin variable-like conformation.  This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.<ref>PMID:9916707</ref>
*<scene name='55/551462/Cv/2'>CD8α, CD8β and antibody</scene> ([[3b9k]]).<ref>PMID:18929574</ref>


== 3D Structures of CD8 ==
== 3D Structures of CD8 ==
[[CD8 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
 
[[1cd8]] – hCD8  extracellular domain – human <BR />
 
===CD8α===
 
[[2hp4]] - hCD8  extracellular domain (mutant) <BR />
[[1akj]] - hCD8  extracellular domain + class I MHC + β-2-microglobulin + HIV reverse transcriptase peptide <BR />
[[3qzw]] - hCD8  extracellular domain + class I MHC + β-2-microglobulin + NEF peptide <BR />
[[1bqh]] - mCD8  extracellular domain + class I MHC + β-2-microglobulin + VSV8 peptide - mouse<BR />
[[3dmm]] - mCD8  extracellular domain + class I MHC + β-2-microglobulin + peptide <BR />
[[1nez]] - mCD8  extracellular domain + class I MHC + β-2-microglobulin <BR />
[[1q69]] - hCD8  residues 209-227 + Lck peptide - NMR<BR />
[[2arj]] - rCD8  extracellular domain + antibody - rat <BR />
[[2q3a]] – CD8  extracellular domain – rhesus monkey <BR />
 
===CD8α and CD8β===


[[2atp]] - mCD8 + CD8α CD8β linker<BR />
== References ==
[[3b9k]] - mCD8 + antibody <BR />
<references/>
[[Category: Topic Page]]
Retrieved from "https://proteopedia.org/CD8"