4npl: Difference between revisions
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== | ==Crystal structure of Zebrafish ALKBH5 in complex with alpha-ketoglutarate== | ||
[[http://www.uniprot.org/uniprot/ALKB5_DANRE ALKB5_DANRE | <StructureSection load='4npl' size='340' side='right'caption='[[4npl]], [[Resolution|resolution]] 1.65Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4npl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NPL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.651Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4npl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npl OCA], [https://pdbe.org/4npl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4npl RCSB], [https://www.ebi.ac.uk/pdbsum/4npl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4npl ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ALKB5_DANRE ALKB5_DANRE] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity). | |||
== | ==See Also== | ||
[[ | *[[Dioxygenase 3D structures|Dioxygenase 3D structures]] | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Danio rerio]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Chen W]] | |||
[[Category: He C]] | |||
[[Category: Zhang L]] | |||
Latest revision as of 12:34, 1 March 2024
Crystal structure of Zebrafish ALKBH5 in complex with alpha-ketoglutarate
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