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{{STRUCTURE_4kbo|  PDB=4kbo  |  SCENE=  }}
===Crystal structure of the human Mortalin (GRP75) ATPase domain in the apo form===


==Function==
==Crystal structure of the human Mortalin (GRP75) ATPase domain in the apo form==
[[http://www.uniprot.org/uniprot/GRP75_HUMAN GRP75_HUMAN]] Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone.  
<StructureSection load='4kbo' size='340' side='right'caption='[[4kbo]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4kbo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KBO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KBO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kbo OCA], [https://pdbe.org/4kbo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kbo RCSB], [https://www.ebi.ac.uk/pdbsum/4kbo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kbo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GRP75_HUMAN GRP75_HUMAN] Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Mortalin, a member of the Hsp70-family of molecular chaperones, functions in a variety of processes including mitochondrial protein import and quality control, Fe-S cluster protein biogenesis, mitochondrial homeostasis, and regulation of p53. Mortalin is implicated in regulation of apoptosis, cell stress response, neurodegeneration, and cancer and is a target of the antitumor compound MKT-077. Like other Hsp70-family members, Mortalin consists of a nucleotide-binding domain (NBD) and a substrate-binding domain. We determined the crystal structure of the NBD of human Mortalin at 2.8 A resolution. Although the Mortalin nucleotide-binding pocket is highly conserved relative to other Hsp70 family members, we find that its nucleotide affinity is weaker than that of Hsc70. A Parkinson's disease-associated mutation is located on the Mortalin-NBD surface and may contribute to Mortalin aggregation. We present structure-based models for how the Mortalin-NBD may interact with the nucleotide exchange factor GrpEL1, with p53, and with MKT-077. Our structure may contribute to the understanding of disease-associated Mortalin mutations and to improved Mortalin-targeting antitumor compounds.


==About this Structure==
Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone.,Amick J, Schlanger SE, Wachnowsky C, Moseng MA, Emerson CC, Dare M, Luo WI, Ithychanda SS, Nix JC, Cowan JA, Page RC, Misra S Protein Sci. 2014 Mar 29. doi: 10.1002/pro.2466. PMID:24687350<ref>PMID:24687350</ref>
[[4kbo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KBO OCA].
 
[[Category: Amick, J.]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Misra, S.]]
</div>
[[Category: Nix, J C.]]
<div class="pdbe-citations 4kbo" style="background-color:#fffaf0;"></div>
[[Category: Page, R C.]]
== References ==
[[Category: Atp binding]]
<references/>
[[Category: Atpase]]
__TOC__
[[Category: Signaling protein]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Amick J]]
[[Category: Misra S]]
[[Category: Nix JC]]
[[Category: Page RC]]
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