4gsc: Difference between revisions
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== | ==Structure analysis of insulin degrading enzyme with compound bdm41559 ((s)-2-[2-(carboxymethyl-phenethyl-amino)-acetylamino]-3-(1h-imidazol-4-yl)-propionic acid methyl ester)== | ||
[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN | <StructureSection load='4gsc' size='340' side='right'caption='[[4gsc]], [[Resolution|resolution]] 2.81Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4gsc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GSC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGW:METHYL+N-(CARBOXYMETHYL)-N-(2-PHENYLETHYL)GLYCYL-L-HISTIDINATE'>MGW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsc OCA], [https://pdbe.org/4gsc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gsc RCSB], [https://www.ebi.ac.uk/pdbsum/4gsc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsc ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | |||
==See Also== | ==See Also== | ||
*[[Insulin- | *[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]] | ||
== References == | |||
== | <references/> | ||
<references | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Deprez | [[Category: Large Structures]] | ||
[[Category: Deprez-Poulain | [[Category: Deprez B]] | ||
[[Category: Guo | [[Category: Deprez-Poulain R]] | ||
[[Category: Tang | [[Category: Guo Q]] | ||
[[Category: Tang WJ]] | |||
Latest revision as of 15:55, 14 March 2024
Structure analysis of insulin degrading enzyme with compound bdm41559 ((s)-2-[2-(carboxymethyl-phenethyl-amino)-acetylamino]-3-(1h-imidazol-4-yl)-propionic acid methyl ester)
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