Insulin-degrading enzyme 3D structures

3D structures of insulin-degrading enzyme

Updated on 30-May-2023

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• Insulin-degrading enzyme
  • 2jg4 - hIDE (mutant) – human
    
  • 3qz2 - hIDE
    
  • 6bf6, 6b7y, 7rze, 7rzf, 7rzg, 7rzh, 7rzi – hIDE – Cryo EM
    
  • 3p7l - rIDE – rat
    
• Insulin-degrading enzyme binary complexes
  • 3n56, 3n57 – hIDE (mutant) + B-type natriuretic peptide
    
  • 3ofi - hIDE + ubiquitin
    
  • 3h44 - hIDE (mutant) + C-C motif chemokine 3
    
  • 4ral - hIDE (mutant) + C-C motif chemokine 4
    
  • 3hgz, 2g48 - hIDE (mutant) + amylin
    
  • 3e4z - hIDE (mutant) + insulin-like growth factor II
    
  • 3e50 - hIDE (mutant) + Transforming growth factor α
    
  • 3e4a – hIDE (mutant) + hydroxamate peptide II1
    
  • 2wby, 2wc0 - hIDE (mutant) + insulin
    
  • 3cww - hIDE (mutant) + Bradykinin N terminal peptide
    
  • 2jbu - hIDE (mutant) + co-purified peptide
    
  • 2g47, 2wk3 - hIDE (mutant) + amyloid β A4 residues 1-40
    
  • 2g49 - hIDE (mutant) + glucagons
    
  • 2g56 - hIDE + insulin β chain
    
  • 4dtt, 4dwk, 4nxo, 4qia, 7k1d, 7k1e, 7k1f – hIDE + inhibitor
    
  • 4gs8, 4gsc, 4gsf, 4ifh, 2ypu, 4lte, 4pf7, 4pf9, 4pfc, 4re9, 6mq3 - hIDE (mutant) + inhibitor
    
  • 3p7o - rIDE (mutant) + peptide
    
  • 4iof – hIDE + antibody
    
  • 5uoe – hIDE (mutant) + antibody
    
  • 6bf7, 6bf9, 6b7z – hIDE + antibody – Cryo EM
    
  • 6bf8, 6bfc, 6b3q – hIDE + insulin – Cryo EM
    
• Insulin-degrading enzyme ternary complexes
  • 4m1c – hIDE + antibody + amyloid β A4 protein residues 1-40
    
  • 6eds - hIDE (mutant) + glucagon + inhibitor
    
  • 2g54 - hIDE (mutant) + insulin chain + Zn
    
  • 4pes, 6byz - hIDE (mutant) + inhibitor + tripeptide
    
  • 6b70 – hIDE + antibody + insulin – Cryo EM
    
  • 5wob – hIDE + antibody + insulin
    
  • 5cjo – hIDE (mutant) + antibody + insulin
    
  • 3tuv - rIDE + peptide + ATP

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Michal Harel, Joel L. Sussman