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==Solution NMR Structure of a putative Uracil DNA glycosylase from Methanosarcina acetivorans, Northeast Structural Genomics Consortium Target MvR76==
==Solution NMR Structure of a putative Uracil DNA glycosylase from Methanosarcina acetivorans, Northeast Structural Genomics Consortium Target MvR76==
<StructureSection load='2l3f' size='340' side='right' caption='[[2l3f]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2l3f' size='340' side='right'caption='[[2l3f]]' scene=''>
== Structural highlights ==
== Structural highlights ==
[[2l3f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_acetivorans Methanosarcina acetivorans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3F OCA]. <br>
<table><tr><td colspan='2'>[[2l3f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_acetivorans Methanosarcina acetivorans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3F FirstGlance]. <br>
<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3f OCA], [https://pdbe.org/2l3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3f RCSB], [https://www.ebi.ac.uk/pdbsum/2l3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HDG_METAC HDG_METAC] Excises hypoxanthine, a deamination product of adenine, from double-stranded DNA. Acts on double-stranded DNA containing G/I, T/I, A/I and C/I base pairs, but not on single-stranded inosine-containing DNA. Has also minor xanthine DNA glycosylase activity. Lacks any detectable uracil-DNA glycosylase activity.<ref>PMID:21642431</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Methanosarcina acetivorans]]
[[Category: Methanosarcina acetivorans]]
[[Category: Acton, T B.]]
[[Category: Acton TB]]
[[Category: Aramini, J M.]]
[[Category: Aramini JM]]
[[Category: Ciccosanti, C T.]]
[[Category: Ciccosanti CT]]
[[Category: Everett, J K.]]
[[Category: Everett JK]]
[[Category: Hamilton, K.]]
[[Category: Hamilton K]]
[[Category: Lee, H W.]]
[[Category: Lee HW]]
[[Category: Montelione, G T.]]
[[Category: Montelione GT]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Rost B]]
[[Category: Rost, B.]]
[[Category: Wang H]]
[[Category: Wang, H.]]
[[Category: Xiao R]]
[[Category: Xiao, R.]]
[[Category: Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Structural genomic]]
[[Category: Unknown function]]
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