4aa7: Difference between revisions
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==E.coli GlmU in complex with an antibacterial inhibitor== | ==E.coli GlmU in complex with an antibacterial inhibitor== | ||
<StructureSection load='4aa7' size='340' side='right' caption='[[4aa7]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='4aa7' size='340' side='right'caption='[[4aa7]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4aa7]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4aa7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AA7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AA7 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=R82:N-(2,4-DIMETHOXY-5-{[(2R)-2-METHYL-2,3-DIHYDRO-1H-INDOL-1-YL]SULFONYL}PHENYL)ACETAMIDE'>R82</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R82:N-(2,4-DIMETHOXY-5-{[(2R)-2-METHYL-2,3-DIHYDRO-1H-INDOL-1-YL]SULFONYL}PHENYL)ACETAMIDE'>R82</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aa7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aa7 OCA], [https://pdbe.org/4aa7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aa7 RCSB], [https://www.ebi.ac.uk/pdbsum/4aa7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aa7 ProSAT]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/GLMU_ECOLI GLMU_ECOLI] Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.<ref>PMID:8083170</ref> <ref>PMID:8555230</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 15: | Line 18: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4aa7" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[N-acetylglucosamine-1-phosphate uridyltransferase|N-acetylglucosamine-1-phosphate uridyltransferase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli K-12]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Breed J]] | ||
[[Category: | [[Category: Ogg DJ]] | ||
[[Category: | [[Category: Otterbein L]] | ||
Latest revision as of 11:22, 20 December 2023
E.coli GlmU in complex with an antibacterial inhibitor
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