Squalene synthase: Difference between revisions
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<StructureSection load=' | <StructureSection load='3wca' size='350' side='right' caption='Structure of SQS complex with FPP analog and Mg+2 ions (green) (PDB code [[3wca]]).' scene='59/591996/Cv/1'> | ||
__TOC__ | |||
== Function == | == Function == | ||
'''Squalene synthase''' (SQS) catalyzes the conversion of 2 molecules of farnesyl pyrophosphate (FPP) to the isoprenoid squalene. SQS is part of the isoprenoid biosynthesis pathway. | '''Squalene synthase''' (SQS) catalyzes the conversion of 2 molecules of farnesyl pyrophosphate (FPP) to the isoprenoid squalene. SQS is part of the isoprenoid biosynthesis pathway. SQS catalysis is the first step in the sterols synthesis including cholesterol<ref>PMID:11008488</ref>. | ||
*'''Dehydrosqualene synthase''' or '''phytene synthase''' catalyzes the condensation of farnesyl diphosphate producing presqualene diphosphate<ref>PMID:21098670</ref>. | |||
== Relevance == | == Relevance == | ||
SQS inhibitors are tested for antihyperlipidemic and antiatherosclerotic agents<ref>PMID:21864285</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
The <scene name='59/591996/Cv/6'>active site of SQS contains a substrate analog</scene><ref>PMID:24789335</ref>. Water molecules are shown as red spheres. <scene name='59/591996/Cv/7'>Mg coordination site</scene>. | |||
==3D structures of squalene synthase== | ==3D structures of squalene synthase== | ||
[[Squalene synthase 3D structures]] | |||
[[ | |||
== References == | == References == | ||
<references/> | <references/> | ||
</StructureSection> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 07:47, 14 August 2024
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