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[[Image:1h6i.gif|left|200px]]


{{Structure
==A REFINED STRUCTURE OF HUMAN AQUAPORIN 1==
|PDB= 1h6i |SIZE=350|CAPTION= <scene name='initialview01'>1h6i</scene>, resolution 3.54&Aring;
<StructureSection load='1h6i' size='340' side='right'caption='[[1h6i]], [[Resolution|resolution]] 3.54&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1h6i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H6I FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron crystallography, [[Resolution|Resolution]] 3.54&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h6i OCA], [https://pdbe.org/1h6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h6i RCSB], [https://www.ebi.ac.uk/pdbsum/1h6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h6i ProSAT]</span></td></tr>
}}
</table>
== Function ==
[https://www.uniprot.org/uniprot/AQP1_HUMAN AQP1_HUMAN] Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.<ref>PMID:1373524</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h6/1h6i_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h6i ConSurf].
<div style="clear:both"></div>


'''A REFINED STRUCTURE OF HUMAN AQUAPORIN 1'''
==See Also==
 
*[[Aquaporin|Aquaporin]]
 
*[[Aquaporin 3D structures|Aquaporin 3D structures]]
==Overview==
== References ==
A refined structure of the human water channel aquaporin-1 is presented. The model rests on the high resolution X-ray structure of the homologous bacterial glycerol transporter GlpF, electron crystallographic data at 3.8 A resolution and a multiple sequence alignment of the aquaporin superfamily. The crystallographic R and free R values (36.7% and 37.8%) for the refined structure are significantly lower than for previous models. Improved geometry and enhanced stability in molecular dynamics simulations demonstrate a significant improvement of the aquaporin-1 structure. Comparison with previous aquaporin-1 models shows significant differences, not only in the loop regions, but also in the core of the water channel.
<references/>
 
__TOC__
==Disease==
</StructureSection>
Known diseases associated with this structure: Aquaporin-1 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=107776 107776]], Blood group, Colton OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=107776 107776]]
 
==About this Structure==
1H6I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H6I OCA].
 
==Reference==
A refined structure of human aquaporin-1., de Groot BL, Engel A, Grubmuller H, FEBS Lett. 2001 Aug 31;504(3):206-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11532455 11532455]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Engel, A.]]
[[Category: De Groot BL]]
[[Category: Groot, B L.De.]]
[[Category: Engel A]]
[[Category: Grubmuller, H.]]
[[Category: Grubmuller H]]
[[Category: electron diffraction]]
[[Category: electron microscopy]]
[[Category: membrane protein]]
[[Category: two-dimensional crystal]]
[[Category: water channel]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:32:54 2008''

Latest revision as of 11:28, 27 March 2024

A REFINED STRUCTURE OF HUMAN AQUAPORIN 1

1h6i, resolution 3.54Å

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