4v10: Difference between revisions
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==Skelemin Association with alpha2b,beta3 Integrin: A Structural Model== | |||
<StructureSection load='4v10' size='340' side='right'caption='[[4v10]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4v10]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V10 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v10 OCA], [https://pdbe.org/4v10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v10 RCSB], [https://www.ebi.ac.uk/pdbsum/4v10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v10 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MYOM1_MOUSE MYOM1_MOUSE] May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. May also contact myosin filaments. Also binds beta-integrins. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Over the last two decades, our knowledge concerning intracellular events that regulate integrin's affinity to their soluble ligands has significantly improved. However, the mechanism of adhesion-induced integrin clustering and development of focal complexes, which could further mature to form focal adhesions, still remains under-investigated. Here we present a structural model of tandem IgC2 domains of skelemin in complex with the cytoplasmic tails of integrin alphaIIbbeta3. The model is generated based upon NMR data and this tertiary assembly illuminates a potential link between the essential cell adhesion receptors and myosin filaments. This connection may serve as a basis for generating the mechanical forces necessary for cell migration and remodeling. | |||
Skelemin Association with AlphaIIbBeta3 Integrin: A Structural Model.,Gorbatyuk V, Nguyen K, Podolnikova NP, Deshmukh L, Lin X, Ugarova TP, Vinogradova O Biochemistry. 2014 Sep 15. PMID:25224262<ref>PMID:25224262</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4v10" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Myomesin|Myomesin]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Deshmukh L]] | |||
[[Category: Gorbatyuk V]] | |||
[[Category: Nguyen K]] | |||
[[Category: Vinogradova O]] | |||
Latest revision as of 06:00, 19 June 2024
Skelemin Association with alpha2b,beta3 Integrin: A Structural Model
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