4wm7: Difference between revisions
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The | ==Crystal Structure of Human Enterovirus D68 in Complex with Pleconaril== | ||
<StructureSection load='4wm7' size='340' side='right'caption='[[4wm7]], [[Resolution|resolution]] 2.32Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4wm7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterovirus_D68 Enterovirus D68]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WM7 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.32Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=W11:3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE'>W11</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wm7 OCA], [https://pdbe.org/4wm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wm7 RCSB], [https://www.ebi.ac.uk/pdbsum/4wm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wm7 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q9YLJ3_HED68 Q9YLJ3_HED68] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Enterovirus D68 (EV-D68) is a member of Picornaviridae and is a causative agent of recent outbreaks of respiratory illness in children in the United States. We report here the crystal structures of EV-D68 and its complex with pleconaril, a capsid-binding compound that had been developed as an anti-rhinovirus drug. The hydrophobic drug-binding pocket in viral protein 1 contained density that is consistent with a fatty acid of about 10 carbon atoms. This density could be displaced by pleconaril. We also showed that pleconaril inhibits EV-D68 at a half-maximal effective concentration of 430 nanomolar and might, therefore, be a possible drug candidate to alleviate EV-D68 outbreaks. | |||
Virus structure. Structure and inhibition of EV-D68, a virus that causes respiratory illness in children.,Liu Y, Sheng J, Fokine A, Meng G, Shin WH, Long F, Kuhn RJ, Kihara D, Rossmann MG Science. 2015 Jan 2;347(6217):71-4. doi: 10.1126/science.1261962. PMID:25554786<ref>PMID:25554786</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4wm7" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Enterovirus D68]] | |||
[[Category: Large Structures]] | |||
[[Category: Fokine A]] | |||
[[Category: Kuhn RJ]] | |||
[[Category: Liu Y]] | |||
[[Category: Long F]] | |||
[[Category: Meng G]] | |||
[[Category: Rossmann MG]] | |||
[[Category: Sheng J]] | |||
Latest revision as of 00:54, 28 December 2023
Crystal Structure of Human Enterovirus D68 in Complex with Pleconaril
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