CD4: Difference between revisions

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<StructureSection load='2nxy' size='350' side='right' caption='Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (grey), TRIS and hexane-diol (PDB entry [[2nxy]])' scene=''>
<StructureSection load='2nxy' size='350' side='right' caption='Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry [[2nxy]])' scene='55/551234/Cv/1'>
   
'''CD4''' (or '''Cluster of Differentiation 4''') is a glycoprotein found on the surface of immune cells.  CD4 has 4 immunoglobulin (Ig) domains, a transmembrane domain and a cytoplasmic tail domain.  D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain.  The D1 domain interacts with class II MHC molecules.  CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells.  The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway.  HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.
</StructureSection>


==3D structures of CD4==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
== Function ==
{{#tree:id=OrganizedByTopic|openlevels=0|
   
'''CD4''' (or '''Cluster of Differentiation 4''' or '''T cell surface glycoprotein CD4''') is a glycoprotein found on the surface of immune cells.  CD4 has 4 immunoglobulin (Ig) domains (D1-D4), a transmembrane domain and a cytoplasmic tail domain.  D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain.  The D1 domain interacts with class II MHC molecules.  CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells.  The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway. 


*CD4 domains
== Relevance ==


**[[1cid]] – rCD4 D3 and D4 domains - rat<BR />
HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.<ref>PMID:8493535</ref>
**[[3cd4]], [[1cdh]], [[1cdi]], [[1cdj]] – hCD4 D1 and D2 domains - human<BR />
*<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>
**[[1cdu]], [[1cdy]] – hCD4 D1 and D2 domains (mutant)<BR />
**[[1wio]], [[1wip]], [[1wiq]] – hCD4 D1, D2, D3 and D4 domains <BR />
**[[2klu]] – hCD4 transmembrane and tail domains - NMR<BR />


*CD4 binary complex
==3D structures of CD4==
[[CD4 3D structures]]


**[[1q68]] – hCD4 tail + Lck peptide - NMR<BR />
</StructureSection>
**[[3b71]] – hCD4 tail + focal adhesion kinase 1<BR />
**[[3o2d]] – hCD4 D1 and D2 domains + antibody <BR />
 
*CD4 ternary complex


**[[1gc1]], [[1g9m]], [[1g9n]], [[1rzj]], [[1rzk]], [[2b4c]], [[2nxy]], [[2nxz]], [[2ny0]], [[2ny1]], [[2ny2]], [[2ny3]], [[2ny4]], [[2ny5]], [[2ny6]], [[3jwd]], [[3jwo]], [[4jm2]] – hCD4 D1 and D2 domains + antibody + gp120<BR />
== References ==
**[[2qad]], [[3lqa]] – hCD4 D1 and D2 domains + antibody + gp160<BR />
<references/>
**[[1jl4]] – hCD4 D1 and D2 domains + class II MHC + ovotransferin peptide<BR />
**[[3s4s]] – hCD4 D1 and D2 domains + class II MHC + haemaglutinin peptide<BR />
**[[3s5l]] – hCD4 D1 and D2 domains + class II MHC + HA peptide<BR />
**[[3t0e]] – hCD4 D1 and D2 domains + class II MHC + TCR<BR />
}}
[[Category: Topic Page]]
[[Category: Topic Page]]

Latest revision as of 08:57, 1 May 2019

Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry 2nxy)

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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