4a7a: Difference between revisions
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==Crystal structure of human monoamine oxidase B (MAO B) in complex with rosiglitazone== | ==Crystal structure of human monoamine oxidase B (MAO B) in complex with rosiglitazone== | ||
<StructureSection load='4a7a' size='340' side='right' caption='[[4a7a]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='4a7a' size='340' side='right'caption='[[4a7a]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4a7a]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4a7a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A7A FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=RGZ:(R)-ROSIGLITAZONE'>RGZ</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a7a OCA], [https://pdbe.org/4a7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a7a RCSB], [https://www.ebi.ac.uk/pdbsum/4a7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a7a ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4a7a" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Aldeco | [[Category: Aldeco M]] | ||
[[Category: Binda | [[Category: Binda C]] | ||
[[Category: Edmondson | [[Category: Edmondson DE]] | ||
[[Category: Geldenhuys | [[Category: Geldenhuys WJ]] | ||
[[Category: Mattevi | [[Category: Mattevi A]] | ||
[[Category: Tortorici | [[Category: Tortorici M]] | ||
Latest revision as of 11:21, 20 December 2023
Crystal structure of human monoamine oxidase B (MAO B) in complex with rosiglitazone
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