4i0h: Difference between revisions
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==SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors.== | ==SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors.== | ||
<StructureSection load='4i0h' size='340' side='right' caption='[[4i0h]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='4i0h' size='340' side='right'caption='[[4i0h]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4i0h]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4i0h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I0H FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1BL:(2R)-5-{[(2S,3R)-4-{[1-(3-TERT-BUTYLPHENYL)CYCLOHEXYL]AMINO}-1-(3,5-DIFLUOROPHENYL)-3-HYDROXYBUTAN-2-YL]AMINO}-2-HYDROXY-5-OXOPENTANOIC+ACID'>1BL</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1BL:(2R)-5-{[(2S,3R)-4-{[1-(3-TERT-BUTYLPHENYL)CYCLOHEXYL]AMINO}-1-(3,5-DIFLUOROPHENYL)-3-HYDROXYBUTAN-2-YL]AMINO}-2-HYDROXY-5-OXOPENTANOIC+ACID'>1BL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i0h OCA], [https://pdbe.org/4i0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i0h RCSB], [https://www.ebi.ac.uk/pdbsum/4i0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i0h ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
==See Also== | ==See Also== | ||
*[[Beta secretase|Beta secretase]] | *[[Beta secretase 3D structures|Beta secretase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Brecht | [[Category: Brecht E]] | ||
[[Category: Yao | [[Category: Yao N]] | ||
Latest revision as of 03:01, 21 November 2024
SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors.
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