1r33: Difference between revisions

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[[Image:1r33.gif|left|200px]]


{{Structure
==Golgi alpha-mannosidase II complex with 5-thio-D-mannopyranosylamine==
|PDB= 1r33 |SIZE=350|CAPTION= <scene name='initialview01'>1r33</scene>, resolution 1.80&Aring;
<StructureSection load='1r33' size='340' side='right'caption='[[1r33]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=LKA:5-THIO-A/B-D-MANNOPYRANOSYLAMINE'>LKA</scene> and <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
<table><tr><td colspan='2'>[[1r33]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R33 FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,3-1,6-alpha-mannosidase Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.114 3.2.1.114]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
|GENE= ALPHA-MAN-II OR GMII OR CG18474/CG18802/CG8139 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LKA:5-THIO-A/B-D-MANNOPYRANOSYLAMINE'>LKA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r33 OCA], [https://pdbe.org/1r33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r33 RCSB], [https://www.ebi.ac.uk/pdbsum/1r33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r33 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAN2_DROME MAN2_DROME] Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r3/1r33_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r33 ConSurf].
<div style="clear:both"></div>


'''Golgi alpha-mannosidase II complex with 5-thio-D-mannopyranosylamine'''
==See Also==
 
*[[Mannosidase 3D structures|Mannosidase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1R33 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R33 OCA].
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Kavelekar LM]]
[[Category: Kavelekar, L M.]]
[[Category: Kuntz DA]]
[[Category: Kuntz, D A.]]
[[Category: Pinto BM]]
[[Category: Pinto, B M.]]
[[Category: Rose DR]]
[[Category: Rose, D R.]]
[[Category: Xin W]]
[[Category: Xin, W.]]
[[Category: LKA]]
[[Category: MPD]]
[[Category: NAG]]
[[Category: ZN]]
[[Category: glycosyl hydrolase family 38]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:46:10 2008''

Latest revision as of 00:25, 21 November 2024

Golgi alpha-mannosidase II complex with 5-thio-D-mannopyranosylamine

1r33, resolution 1.80Å

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