4ifh: Difference between revisions
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==Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619== | ==Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619== | ||
<StructureSection load='4ifh' size='340' side='right' caption='[[4ifh]], [[Resolution|resolution]] 3.29Å' scene=''> | <StructureSection load='4ifh' size='340' side='right'caption='[[4ifh]], [[Resolution|resolution]] 3.29Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ifh]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4ifh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4gse 4gse]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IFH FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1EF:N-({1-[(2R)-4-(HYDROXYAMINO)-1-(NAPHTHALEN-2-YL)-4-OXOBUTAN-2-YL]-1H-1,2,3-TRIAZOL-4-YL}METHYL)-4-METHYLBENZAMIDE'>1EF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.286Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1EF:N-({1-[(2R)-4-(HYDROXYAMINO)-1-(NAPHTHALEN-2-YL)-4-OXOBUTAN-2-YL]-1H-1,2,3-TRIAZOL-4-YL}METHYL)-4-METHYLBENZAMIDE'>1EF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ifh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ifh OCA], [https://pdbe.org/4ifh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ifh RCSB], [https://www.ebi.ac.uk/pdbsum/4ifh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ifh ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | |||
==See Also== | ==See Also== | ||
*[[Insulin- | *[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]] | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Deprez | [[Category: Deprez B]] | ||
[[Category: Deprez | [[Category: Deprez R]] | ||
[[Category: Guo | [[Category: Guo Q]] | ||
[[Category: Liang | [[Category: Liang WG]] | ||
[[Category: Tang | [[Category: Tang W]] | ||
Latest revision as of 11:55, 1 March 2024
Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619
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