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==Crystal Structure of Trypanosoma Brucei phosphomannosemutase, TB.10.700.370==
==Crystal Structure of Trypanosoma Brucei phosphomannosemutase, TB.10.700.370==
<StructureSection load='3f9r' size='340' side='right' caption='[[3f9r]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='3f9r' size='340' side='right'caption='[[3f9r]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3f9r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F9R FirstGlance]. <br>
<table><tr><td colspan='2'>[[3f9r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F9R FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tb10.70.0370, TB10.700.370 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphomannomutase Phosphomannomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.8 5.4.2.8] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9r OCA], [https://pdbe.org/3f9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f9r RCSB], [https://www.ebi.ac.uk/pdbsum/3f9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f9r ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f9r RCSB], [http://www.ebi.ac.uk/pdbsum/3f9r PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q38AW2_9TRYP Q38AW2_9TRYP]] Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions (By similarity).[RuleBase:RU361118]  
[https://www.uniprot.org/uniprot/Q38AW2_TRYB2 Q38AW2_TRYB2] Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.[RuleBase:RU361118]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/3f9r_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/3f9r_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f9r ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>


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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Phosphomannomutase]]
[[Category: Large Structures]]
[[Category: Trypanosoma brucei]]
[[Category: Trypanosoma brucei]]
[[Category: Ali, A]]
[[Category: Ali A]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bandini, G]]
[[Category: Bandini G]]
[[Category: Bochkarev, A]]
[[Category: Bochkarev A]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Cossar, D]]
[[Category: Cossar D]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: Ferguson, M A.J]]
[[Category: Ferguson MAJ]]
[[Category: Guther, L]]
[[Category: Guther L]]
[[Category: Hui, R]]
[[Category: Hui R]]
[[Category: Kozieradzki, I]]
[[Category: Kozieradzki I]]
[[Category: Lam, A]]
[[Category: Lam A]]
[[Category: Lin, Y H]]
[[Category: Lin YH]]
[[Category: MacKenzie, F]]
[[Category: MacKenzie F]]
[[Category: Qiu, W]]
[[Category: Qiu W]]
[[Category: Structural genomic]]
[[Category: Schapira M]]
[[Category: Schapira, M]]
[[Category: Shamshad A]]
[[Category: Shamshad, A]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Wernimont AK]]
[[Category: Wernimont, A K]]
[[Category: Zhao Y]]
[[Category: Zhao, Y]]
[[Category: Isomerase]]
[[Category: Sgc]]

Latest revision as of 00:29, 28 December 2023

Crystal Structure of Trypanosoma Brucei phosphomannosemutase, TB.10.700.370

3f9r, resolution 1.85Å

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