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[[Image:2ajp.gif|left|200px]]


{{Structure
==Crystal structure of a human pyridoxal kinase==
|PDB= 2ajp |SIZE=350|CAPTION= <scene name='initialview01'>2ajp</scene>, resolution 2.500&Aring;
<StructureSection load='2ajp' size='340' side='right'caption='[[2ajp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene> and <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER'>ANP</scene>
<table><tr><td colspan='2'>[[2ajp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AJP FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Pyridoxal_kinase Pyridoxal kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.35 2.7.1.35]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
|GENE= PDXK, PKH, PNK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ajp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajp OCA], [https://pdbe.org/2ajp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ajp RCSB], [https://www.ebi.ac.uk/pdbsum/2ajp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ajp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDXK_HUMAN PDXK_HUMAN] Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aj/2ajp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ajp ConSurf].
<div style="clear:both"></div>


'''Crystal structure of a human pyridoxal kinase'''
==See Also==
 
*[[Pyridoxal kinase|Pyridoxal kinase]]
 
__TOC__
==Disease==
</StructureSection>
Known diseases associated with this structure: Paroxysmal nonkinesigenic dyskinesia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609023 609023]], Polycystic kidney and hepatic disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606702 606702]]
 
==About this Structure==
2AJP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJP OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Pyridoxal kinase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Arrowsmith C]]
[[Category: Arrowsmith, C.]]
[[Category: Atanassova A]]
[[Category: Atanassova, A.]]
[[Category: Bochkarev A]]
[[Category: Bochkarev, A.]]
[[Category: Dimov S]]
[[Category: Dimov, S.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Ismail S]]
[[Category: Ismail, S.]]
[[Category: Park H]]
[[Category: Park, H.]]
[[Category: Sundstrom M]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Tempel W]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt J]]
[[Category: Tempel, W.]]
[[Category: Weigelt, J.]]
[[Category: ANP]]
[[Category: MG]]
[[Category: UNX]]
[[Category: pyridoxal kinase]]
[[Category: sgc]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:50:30 2008''

Latest revision as of 07:25, 23 August 2023

Crystal structure of a human pyridoxal kinase

2ajp, resolution 2.50Å

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