2yur: Difference between revisions
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==Solution structure of the Ring finger of human Retinoblastoma-binding protein 6== | ==Solution structure of the Ring finger of human Retinoblastoma-binding protein 6== | ||
<StructureSection load='2yur' size='340' side='right' caption='[[2yur | <StructureSection load='2yur' size='340' side='right'caption='[[2yur]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2yur]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2yur]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YUR FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yur OCA], [https://pdbe.org/2yur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yur RCSB], [https://www.ebi.ac.uk/pdbsum/2yur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yur ProSAT], [https://www.topsan.org/Proteins/RSGI/2yur TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/RBBP6_HUMAN RBBP6_HUMAN] E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yu/2yur_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yu/2yur_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yur ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Retinoblastoma-binding protein|Retinoblastoma-binding protein]] | *[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Abe | [[Category: Large Structures]] | ||
[[Category: Harada | [[Category: Abe H]] | ||
[[Category: Kigawa | [[Category: Harada T]] | ||
[[Category: Koshiba | [[Category: Kigawa T]] | ||
[[Category: Miyamoto | [[Category: Koshiba S]] | ||
[[Category: Miyamoto K]] | |||
[[Category: Tochio | [[Category: Tochio N]] | ||
[[Category: Tomizawa | [[Category: Tomizawa T]] | ||
[[Category: Watanabe | [[Category: Watanabe S]] | ||
[[Category: Yokoyama | [[Category: Yokoyama S]] | ||
Latest revision as of 19:18, 29 May 2024
Solution structure of the Ring finger of human Retinoblastoma-binding protein 6
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