4iim: Difference between revisions
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==Crystal structure of the Second SH3 Domain of ITSN1 bound with a synthetic peptide== | ==Crystal structure of the Second SH3 Domain of ITSN1 bound with a synthetic peptide== | ||
<StructureSection load='4iim' size='340' side='right' caption='[[4iim]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='4iim' size='340' side='right'caption='[[4iim]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4iim]] is a 5 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4iim]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IIM FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iim OCA], [https://pdbe.org/4iim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iim RCSB], [https://www.ebi.ac.uk/pdbsum/4iim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iim ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref> | ||
==See Also== | |||
*[[Intersectin|Intersectin]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Bountra | [[Category: Arrowsmith CH]] | ||
[[Category: Dong | [[Category: Bountra C]] | ||
[[Category: Edwards | [[Category: Dong A]] | ||
[[Category: Gu | [[Category: Edwards AM]] | ||
[[Category: Guan | [[Category: Gu J]] | ||
[[Category: Huang | [[Category: Guan X]] | ||
[[Category: Huang H]] | |||
[[Category: Sidhu | [[Category: Sidhu S]] | ||
[[Category: Tong | [[Category: Tong Y]] | ||
[[Category: Wernimont | [[Category: Wernimont A]] | ||
Latest revision as of 15:23, 20 September 2023
Crystal structure of the Second SH3 Domain of ITSN1 bound with a synthetic peptide
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