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==The crystal structure of Xenopus Glucokinase and Glucokinase Regulatory Protein complex==
==The crystal structure of Xenopus Glucokinase and Glucokinase Regulatory Protein complex==
<StructureSection load='3w0l' size='340' side='right' caption='[[3w0l]], [[Resolution|resolution]] 2.92&Aring;' scene=''>
<StructureSection load='3w0l' size='340' side='right'caption='[[3w0l]], [[Resolution|resolution]] 2.92&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3w0l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W0L FirstGlance]. <br>
<table><tr><td colspan='2'>[[3w0l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W0L FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F6R:FRUCTOSE+-6-PHOSPHATE'>F6R</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.92&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gck ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 Xenopus laevis]), gckr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 Xenopus laevis])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F6R:FRUCTOSE+-6-PHOSPHATE'>F6R</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w0l OCA], [https://pdbe.org/3w0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w0l RCSB], [https://www.ebi.ac.uk/pdbsum/3w0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w0l ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w0l RCSB], [http://www.ebi.ac.uk/pdbsum/3w0l PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GCKR_XENLA GCKR_XENLA]] Inhibits glucokinase by forming an inactive complex with this enzyme.  
[https://www.uniprot.org/uniprot/GCKR_XENLA GCKR_XENLA] Inhibits glucokinase by forming an inactive complex with this enzyme.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3w0l" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Glucokinase Regulatory Protein|Glucokinase Regulatory Protein]]
*[[Glucokinase Regulatory Protein|Glucokinase Regulatory Protein]]
*[[Hexokinase|Hexokinase]]
*[[Hexokinase 3D structures|Hexokinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Glucokinase]]
[[Category: Large Structures]]
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
[[Category: Choi, J M]]
[[Category: Choi JM]]
[[Category: Kim, E]]
[[Category: Kim E]]
[[Category: Kim, H S]]
[[Category: Kim HS]]
[[Category: Kyeong, H H]]
[[Category: Kyeong HH]]
[[Category: Seo, M H]]
[[Category: Seo MH]]
[[Category: Aba sandwich]]
[[Category: Kinase]]
[[Category: Sugar binding]]
[[Category: Transferase-transferase inhibitor complex]]
[[Category: Typical hexokanse fold]]

Latest revision as of 12:45, 8 November 2023

The crystal structure of Xenopus Glucokinase and Glucokinase Regulatory Protein complex

3w0l, resolution 2.92Å

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