Hexokinase 3D structures

3D structures of hexokinase

Updated on 26-August-2025

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• Hexokinase
  • 3o08, 3o1b, 3o1w, 3o4w, 3o6w, 3o80, 4jax – KlHK – Kluyveromyces lactis
    
  • 6vyf, 6vyg - HK – Plasmodium vivax – Cryo EM
    
  • 2e2n – StHK – Sulfolobus tokodaii
    
  • 2e2o - StHK + glucose
    
  • 2e2p – StHK + ADP
    
  • 2e2q - StHK + ADP + xylose + Mg
    
  • 3o5b, 3o8m – KlHK + glucose
    
  • 1bdg – HK + glucose – Schistosoma mansoni
    
  • 6krj, 6ksr - HK – Eimeria tenella
    
  • 6da0 - HK – Naegleria fowleri
    
  • 6edi - HK – Leishmania braziliensis
    
  • 7zzi - HK + glucose – Plasmodium falciparum
    
• Hexokinase I
  • 1dgk – hHK I (mutant) + ADP + glucose – human
    
  • 1cza - hHK I (mutant) + ADP + glucose-6-phosphate + glucose
    
  • 1qha – hHK I + AMP-PNP
    
  • 1hkc - hHK I + phosphate + glucose
    
  • 1hkb, 4f9o - hHK I + glucose-6-phosphate + glucose
    
  • 4fpa - hHK I (mutant) + glucose-6-phosphate + glucose
    
  • 4foe - hHK I + mannose-6-phosphate + glucose
    
  • 4foi - hHK I (mutant) + glucose 1,6-bisphosphate + glucose
    
  • 4fpb - hHK I + 1,5-anhydroglucitol-6-phosphate + glucose
    
  • 1bg3 - raHK I + glucose-6-phosphate + glucose - rat
    
  • 4qs8 - AtHK I – Arabidopsis thaliana
    
  • 4qs7 - AtHK I + glucose
    
  • 4qs9 - AtHK I (mutant) + glucose
    
  • 3b8a – yHK I + glucose – yeast
    
  • 1hkg, 6p4x – yHK I
    
  • 6pdt – yHK I + glucopyranose – Cryo EM
    
  • 6r2n - KlHK I
    
• Hexokinase II or HK VI
  • 2nzt – hHK II
    
  • 5hex, 5hfu, 5hg1 - hHK II + inhibitor
    
  • 5zqt, 6jj4 - rHK II - rice
    
  • 6jj7 - rHK II + glucose
    
  • 6jj8 - rHK II + ATP
    
  • 6jj9 - rHK II + glucose + ATP
    **1ig8, 2yhx – yHK II
    
• Hexokinase III
  • 3hm8 – hHK III C terminal
• Hexokinase IV (Glucokinase GK)
  • 3qic – hGK IV residues 12-465 (mutant)
    
  • 1v4t – hGK
    
  • 3mcp – GK – Parabacterioides distasonis
    
  • 2qm1 – GK – Enterococcus faecalis
    
  • 3vgk – SgGK – Streptomyces griseus
    
  • 1q18 – EcGK – Escherichia coli
    
  • 4eun – GK – Janibacter
    
  • 3vov – GK – Thermus thermophilus
  • 9f3n, 9f3o – KlGK
    
• Hexokinase IV binary complex
  • 3idh - hGK IV residues 12-465 + glucose
    
  • 1v4s, 3a0i, 3goi, 3h1v, 3imx, 3s41, 3vev, 3vf6, 4dch, 4dhy - hGK IV residues 12-465 + synthetic activator
    
  • 3fr0, 4ise, 4isf, 4isg, 4iwv, 4ixc, 4l3q, 4mle, 4mlh, 5v4w, 5v4x, 6e0e, 6e0i - hGK IV residues 12-465 + activator
    
  • 1sz2 - EcGK + glucose
    
  • 3vgm - SgGK + glucose
    
  • 9f3i - KlGK + glucose
    
  • 9f3k - KlGK (mutant) + glucose
    
  • 9f3m - KlGK (mutant) + fructose
    
  • 9f3j - KlGK + mannose
    
  • 9f3l - KlGK (mutant) + mannose
    
• Hexokinase IV ternary complex
  • 3vey - hGK + glucose + ATPgS
    
  • 7t78, 7t79 - hGK IV + glucose + ligand
    
  • 3fgu, 3id8 - hGK IV residues 12-465 + AMP-PNP + glucose
    
  • 3f9m, 4l3q, 4no7, 4rch - hGK IV residues 12-465 + activator + glucose
    
  • 3w0l, 4lc9 – raGK + fructose-6-phosphate + GK regulator
    
  • 2q2r - GK + glucose + ADP – Trypanosoma cruzi
    
  • 3vgl - SgGK + glucose + AMP-PNP
    
• ADP-dependent GK
  • 4b8r – TlAGK – Thermococcus litoralis
    
  • 1gc5 – TlAGK + ADP
    
  • 4b8s – TlAGK + AMP
    
  • 1l2l – AGK – Pyrococcus horikoshii
    
  • 1ua4 - AGK – Pyrococcus furiosus

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Michal Harel