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==Crystal structure of the first PHR domain of the Mouse Myc-binding protein 2 (MYCBP-2)==
==Crystal structure of the first PHR domain of the Mouse Myc-binding protein 2 (MYCBP-2)==
<StructureSection load='3gbw' size='340' side='right' caption='[[3gbw]], [[Resolution|resolution]] 1.32&Aring;' scene=''>
<StructureSection load='3gbw' size='340' side='right'caption='[[3gbw]], [[Resolution|resolution]] 1.32&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3gbw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GBW FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GBW FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.32&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mycbp2, Pam, Rpm-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gbw RCSB], [http://www.ebi.ac.uk/pdbsum/3gbw PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/3gbw TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbw OCA], [https://pdbe.org/3gbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gbw RCSB], [https://www.ebi.ac.uk/pdbsum/3gbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbw ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3gbw TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/MYCB2_MOUSE MYCB2_MOUSE]] Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. May have a role during synaptogenesis; candidate for respiratory distress and ventilatory disorders that arise from defective neuronal control of breathing. May function as a facilitator or regulator of transcriptional activation by MYC.<ref>PMID:14729956</ref> 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbw_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbw_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gbw ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3gbw" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Mus musculus]]
[[Category: Large Structures]]
[[Category: Atwell, S]]
[[Category: Atwell S]]
[[Category: Bain, K T]]
[[Category: Bain KT]]
[[Category: Burley, S K]]
[[Category: Burley SK]]
[[Category: Klemke, R L]]
[[Category: Klemke RL]]
[[Category: Miller, S A]]
[[Category: Miller SA]]
[[Category: Structural genomic]]
[[Category: Ozyurt SA]]
[[Category: Ozyurt, S A]]
[[Category: Rutter ME]]
[[Category: Rutter, M E]]
[[Category: Sampathkumar P]]
[[Category: Sampathkumar, P]]
[[Category: Sauder JM]]
[[Category: Sauder, J M]]
[[Category: Tarun G]]
[[Category: Tarun, G]]
[[Category: Wasserman SR]]
[[Category: Wasserman, S R]]
[[Category: Ligase]]
[[Category: Metal-binding]]
[[Category: Myc-binding protein 2]]
[[Category: Mycbp2]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
[[Category: Nucleus]]
[[Category: Pam]]
[[Category: Phosphoprotein]]
[[Category: Phr domain]]
[[Category: Probable e3 ubiquitin-protein ligase mycbp2]]
[[Category: Protein associated with myc]]
[[Category: PSI, Protein structure initiative]]
[[Category: Rpm-1]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Ubl conjugation pathway]]
[[Category: Zinc-finger]]

Latest revision as of 09:11, 30 October 2024

Crystal structure of the first PHR domain of the Mouse Myc-binding protein 2 (MYCBP-2)

3gbw, resolution 1.32Å

Drag the structure with the mouse to rotate

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