Factor VIII: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
Michal Harel (talk | contribs)
32,831 edits
No edit summary
Michal Harel (talk | contribs)
32,831 edits
No edit summary
 
(13 intermediate revisions by 2 users not shown)
Line 1: Line 1:
{{STRUCTURE_2r7e|  PDB=2r7e | SIZE=400| SCENE=Factor_VIII/Cv/1 |right|CAPTION=Glycosylated human Factor VIII.  Residues 19-760 (grey) 1582-2351 (green) complex with Ca+2 (green) and Cu+2 (orange) ions,  [[2r7e]] }}
<StructureSection load='2r7e' size='350' side='right' scene='45/451726/Cv/2' caption='Glycosylated human Factor VIII.  Residues 19-760 (cyan), 1582-2351 (magenta) complex with Ca+2 (green) and Cu+2 (orange) ions (PDB code [[2r7e]]) '>
== Function ==


[[Factor VIII]] (FVIII) is a blood clotting factor.  Defects in the protein result in hemophilia A.  FVIII is a cofactor for [[Factor IX|factor IXa]]. See also [[Factor VIII (Hebrew)}}.
[[Factor VIII]] (FVIII) is a blood clotting factor.  FVIII is a cofactor for [[Factor IX|factor IXa]]<ref>PMID:2491949</ref> . See also [[Factor VIII (Hebrew)]].


<!--
<scene name='45/451726/Cv/7'>First Ca coordination site</scene>.
===RECOMBINANT HUMAN CELLULAR COAGULATION FACTOR XIII===
The A subunit is composed of an activation peptide and 4 domains: the β-sandwich <scene name='1f13/Chaina_domain1/1'>domain</scene>, the central core domain, the barrel 1 domain, and the
<scene name='1f13/Fxiii_4domains_colored/1'>barrel 2 domain</scene>.-->


{{TOC limit|limit=2}}
<scene name='45/451726/Cv/8'>Second Ca coordination site</scene>.
 
<scene name='45/451726/Cv/9'>First Cu coordination site</scene>.
 
<scene name='45/451726/Cv/10'>Second Cu coordination site</scene> (PDB code [[2r7e]]).<ref>PMID:17965321</ref>
== Disease ==
 
Defects in the protein result in [[Hemophilia|hemophilia]] A.
 
== Relevance ==
 
Factor VIII is given to hemophiliacs in order to restore homestasis.
<br /><br />
<br /><br />
<br />
<br />
<br />
<br />
<br />
<br />
</StructureSection>


== 3D Structures of Factor VIII ==
== 3D Structures of Factor VIII ==
Line 18: Line 28:
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}


[[2r7e]], [[3cdz]], [[3j2q]], [[4bdv]] – hFVIII – human<br />
[[2r7e]], [[3cdz]], [[3j2q]], [[4bdv]], [[6mf2]] – hFVIII 19-760+1582-2351 – human<br />
[[3hnb]], [[3hny]], [[3hob]] – hFVIII light chain C2 domain<br />
[[6mf0]] – h/pFVIII<br />
[[3hnb]], [[3hny]], [[3hob]], [[4pt6]] – hFVIII light chain C2 domain 2189-2347<br />
[[1d7p]] - hFVIII light chain C2 domain (mutant)<br />
[[1d7p]] - hFVIII light chain C2 domain (mutant)<br />
[[1cfg]], [[1fac]] - hFVIII light chain C2 domain membrane-binding peptide - NMR<br />
[[1cfg]], [[1fac]] - hFVIII light chain C2 domain membrane-binding peptide - NMR<br />
[[1iqd]] - hFVIII light chain C2 domain (mutant) + monoclonal Fab<br />
[[7k66]], [[7kbt]] – h/pFVIII + antibody<br />
[[4xzu]] - hFVIII light chain C2 domain + monoclonal Fab <br />
[[1iqd]] - hFVIII light chain C2 domain (mutant) + monoclonal Fab<br />
[[3j2s]] - hFVIII light chain 1710-2356<br />
[[5k8d]] - hFVIII heavy chain + light chain residues 104-329<br />
[[7kwo]] – hFVIII + VWF-XTEN<br />
[[4mo3]] - pFVIII light chain C2 domain – pig<br />
[[7s0p]] - pFVIII light chain C2 domain + phosphatidylserine<br />
[[4ki5]] - mFVIII light chain C2 domain + monoclonal Fab – mouse<br />
[[4ki5]] - mFVIII light chain C2 domain + monoclonal Fab – mouse<br />
[[3j2s]] - hFVIII light chain<br />
== References ==
[[4mo3]] - FVIII light chain C2 domain – pig<br />
<references/>
 


[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 08:56, 27 February 2023

Glycosylated human Factor VIII. Residues 19-760 (cyan), 1582-2351 (magenta) complex with Ca+2 (green) and Cu+2 (orange) ions (PDB code 2r7e)

Drag the structure with the mouse to rotate

3D Structures of Factor VIII

Updated on 27-February-2023

factor IXa, Factor VIII (Hebrew), 2r7e, hemophilia, 6mf2 – hFVIII 19-760+1582-2351 – human
6mf0 – h/pFVIII
3hnb, 3hny, 3hob, 4pt6 – hFVIII light chain C2 domain 2189-2347
1d7p - hFVIII light chain C2 domain (mutant)
1cfg, 1fac - hFVIII light chain C2 domain membrane-binding peptide - NMR
7k66, 7kbt – h/pFVIII + antibody
4xzu - hFVIII light chain C2 domain + monoclonal Fab
1iqd - hFVIII light chain C2 domain (mutant) + monoclonal Fab
3j2s - hFVIII light chain 1710-2356
5k8d - hFVIII heavy chain + light chain residues 104-329
7kwo – hFVIII + VWF-XTEN
4mo3 - pFVIII light chain C2 domain – pig
7s0p - pFVIII light chain C2 domain + phosphatidylserine
4ki5 - mFVIII light chain C2 domain + monoclonal Fab – mouse

References

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

Retrieved from "https://proteopedia.org/index.php?title=Factor_VIII&oldid=3722926"