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==Crystal structure of glutaminyl cyclase from drosophila melanogaster in space group I4==
==Crystal structure of glutaminyl cyclase from drosophila melanogaster in space group I4==
<StructureSection load='4fwu' size='340' side='right' caption='[[4fwu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4fwu' size='340' side='right'caption='[[4fwu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4fwu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FWU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FWU FirstGlance]. <br>
<table><tr><td colspan='2'>[[4fwu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FWU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FWU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4f9u|4f9u]], [[4f9v|4f9v]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">QC, CG10487, CG32412, Dmel_CG32412 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fwu OCA], [https://pdbe.org/4fwu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fwu RCSB], [https://www.ebi.ac.uk/pdbsum/4fwu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fwu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fwu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fwu RCSB], [http://www.ebi.ac.uk/pdbsum/4fwu PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/QPCT1_DROME QPCT1_DROME] Acts as a glutaminyl-peptide cyclotransferase (PubMed:17722885, PubMed:22897232). Responsible for the biosynthesis of pyroglutamyl peptides (By similarity). Might be more efficient in the conversion of tri and tetrapeptides in vitro (PubMed:17722885). Might have a relative preference for substrates containing hydrophobic amino acids in vitro (PubMed:17722885).[UniProtKB:Q16769]<ref>PMID:17722885</ref> <ref>PMID:22897232</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4fwu" style="background-color:#fffaf0;"></div>
==See Also==
*[[Glutaminyl cyclase|Glutaminyl cyclase]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Koch, B]]
[[Category: Large Structures]]
[[Category: Kolenko, P]]
[[Category: Koch B]]
[[Category: Stubbs, M T]]
[[Category: Kolenko P]]
[[Category: Alpha/beta hydrolase]]
[[Category: Stubbs MT]]
[[Category: Alzheimer`s disease]]
[[Category: Glycosylation]]
[[Category: Hydrolase]]
[[Category: Pglu formation]]
[[Category: Pglu-amyloid]]
[[Category: Pyroglutamate]]

Latest revision as of 10:52, 6 November 2024

Crystal structure of glutaminyl cyclase from drosophila melanogaster in space group I4

4fwu, resolution 2.00Å

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