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| <StructureSection load='1hqg' size='340' side='right' caption='Structure of rat arginase containing Mn+2 (purple) complex with ornithine and urea (PDB code [[1hqg]]).' scene=''> | | <StructureSection load='1hqg' size='400' side='right' caption='Structure of rat arginase containing Mn+2 (purple) complex with ornithine (cyan) and urea (yellow) (PDB code [[1hqg]]).' scene='59/593950/Cv/1'> |
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| == Function == | | == Function == |
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| '''Arginase''' (Arg) catalyzes the conversion of arginine to ornithine and urea. Arg is the final enzyme in the urea cycle. Arg requires 2 manganese ions for functioning. | | '''Arginase''' (Arg) catalyzes the conversion of arginine to ornithine and urea. Arg is the final enzyme in the urea cycle. Arg requires 2 manganese ions for functioning.<ref>PMID:18360740</ref> |
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| == Disease == | | == Disease == |
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| == Relevance ==
| | Arg deficiency is an inherited disorder causing the accumulation of toxic urea in the blood. |
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| == Structural highlights == | | == Structural highlights == |
| </StructureSection> | | |
| | The manganese ions are located at the bottom of a 15A cleft. <scene name='59/593950/Cv/4'>Active site</scene>. The proposed reaction mechanism involves <scene name='59/593950/Cv/5'>H141, D128, E277</scene> in rat.<ref>PMID:11258880</ref> |
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| ==3D structures of arginase== | | ==3D structures of arginase== |
| | [[Arginase 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Arginase
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| **[[3tf3]] – hArg 1 - human <br />
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| **[[2ef4]], [[2ef5]], [[2eiv]] – Arg – ''Thermus thermophilus'' <br />
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| **[[4rhi]], [[4rhj]], [[4rhk]] – TbArg – ''Trypanosoma brucei''<br />
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| *Mn containing arginase
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| **[[1rla]], [[2rla]] – rArg + Mn – rat<br />
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| **[[3rla]], [[4rla]], [[5rla]], [[1hqx]], [[1p8m]], [[1p8n]], [[1p8o]], [[1p8p]], [[1p8q]], [[1p8r]], [[1p8s]], [[1ta1]], [[1tbh]], [[1tbj]], [[1tbl]], [[3e8q]], [[3e8z]] – rArg (mutant) + Mn <br />
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| **[[1wva]], [[2pha]], [[2zav]] – hArg 1 + Mn <br />
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| **[[1wvb]] – hArg 1 (mutant) + Mn <br />
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| **[[1cev]], [[2cev]] – BcArg + Mn – ''Bacillus caldovelox''<br />
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| **[[4g3h]] – Arg + Mn – ''Helicobacter pylori''<br />
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| **[[4ity]] – LmArg + Mn – ''Leishmania mexicana''<br />
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| **[[4q3p]] – SmArg + Mn – ''Schistosoma mansoni''<br />
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| **[[4rhl]], [[4rhm]], [[4rhq]] – TbArg (mutant) + Mn <br />
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| * ''Mn containing arginase complexes''
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| **[[1d3v]], [[1hq5]] – rArg + Mn + Arg analog<br />
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| **[[1hqf]], [[1hqh]] – rArg + Mn + hydroxyl-Arg <br />
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| **[[1hqg]] – rArg (mutant) + Mn + ornithine + urea<br />
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| **[[1r1o]], [[1t4p]], [[1t4r]], [[1t4t]], [[1t5f]] – rArg + Mn + inhibior<br />
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| **[[1t4s]] – rArg + Mn + valine<br />
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| **[[1t5g]] – rArg + Mn + Arg <br />
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| **[[1zpe]], [[1zpg]] – rArg (mutant) + Mn + alkylamine derivative<br />
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| **[[3e9b]] – rArg (mutant) + Mn + Br-ethyl cysteine<br />
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| **[[2aeb]], [[2pll]] – hArg 1 + Mn + Arg analog<br />
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| **[[2pho]] – hArg 1 + Mn + thiosemicarbazide<br />
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| **[[3dj8]] – hArg 1 + Mn + amino-epoxy octanoic acid<br />
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| **[[3e6k]], [[3e6v]] – hArg 1 (mutant) + Mn + Arg analog<br />
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| **[[3f80]] – hArg 1 + Mn + nitro-norleucine<br />
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| **[[3kv2]], [[3lp7]] – hArg 1 + Mn + nor-ω-hydroxy-Arg<br />
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| **[[3gmz]] – hArg 1 + Mn + ornithine <br />
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| **[[3gn0]] – hArg 1 + Mn + ornithine derivative<br />
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| **[[3lp4]] – hArg 1 + Mn + lysine <br />
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| **[[3mfv]], [[3mfw]] – hArg 1 + Mn + histidine derivative<br />
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| **[[3mjl]] – hArg 1 + Mn + amino-imidazole<br />
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| **[[3sjt]], [[3skk]], [[4hww]], [[4hxq]], [[4ie1]] – hArg 1 + Mn + inhibitor<br />
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| **[[4fci]] – hArg 1 + Mn + amino-guanidino propionate<br />
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| **[[3cev]] – BcArg + Mn + Arg <br />
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| **[[5cev]] – BcArg + Mn + Lys <br />
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| **[[4iu0]], [[4iu1]], [[4iu4]] – LmArg + Mn + inhibitor<br />
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| **[[4iu5]] – LmArg + Mn + ornithine <br />
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| **[[4q3q]], [[4q3r]], [[4q3s]], [[4q3t]], [[4q3u]], [[4q3v]] – SmArg + Mn + inhibitor<br />
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| **[[4q40]], [[4q41]] – SmArg + Mn + amino acid<br />
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| **[[4q42]] – SmArg + Mn + ornithine <br />
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| *Co containing arginase
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| **[[3th7]], [[3the]] – hArg 1 + Co <br />
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| **[[3thh]] – hArg 1 + Co + Arg analog<br />
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| **[[3thj]] – hArg 1 + Co + ornithine <br />
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| **[[4fck]] – hArg 1 + Co + amino-guanidino propionate<br />
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| *Ni containing arginase
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| **[[4gsm]] – hArg 1 + Ni<br />
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| **[[4gsv]] – hArg 1 + Ni + Arg analog<br />
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| *Zn containing arginase
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| **[[4gsz]] – hArg 1 + Zn + Arg analog<br />
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| *Mn and Zn containing arginase
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| **[[4gwc]] – hArg 1 + Mn + Zn<br />
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| **[[4gwd]] – hArg 1 + Mn + Zn + Arg analog<br />
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| *Arginase 2
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| **[[1pq3]] – hArg 2+ Mn <br />
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| **[[4hze]], [[4i06]], [[4ie2]], [[4ie3]], [[4ixu]], [[4ixv]] – hArg 2 + Mn + inhibitor<br />
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| }}
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| == References == | | == References == |
