4u5m: Difference between revisions
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==Structure of a left-handed DNA G-quadruplex== | |||
<StructureSection load='4u5m' size='340' side='right'caption='[[4u5m]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4u5m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U5M FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u5m OCA], [https://pdbe.org/4u5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u5m RCSB], [https://www.ebi.ac.uk/pdbsum/4u5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u5m ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR solution and X-ray crystal structures of a left-handed DNA G-quadruplex. The structure displays unprecedented features that can be exploited as unique recognition elements. | |||
Structure of a left-handed DNA G-quadruplex.,Chung WJ, Heddi B, Schmitt E, Lim KW, Mechulam Y, Phan AT Proc Natl Acad Sci U S A. 2015 Feb 18. pii: 201418718. PMID:25695967<ref>PMID:25695967</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 4u5m" style="background-color:#fffaf0;"></div> | ||
[[Category: Chung | == References == | ||
[[Category: Lim | <references/> | ||
[[Category: Mechulam | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Synthetic construct]] | |||
[[Category: Brahim H]] | |||
[[Category: Chung WJ]] | |||
[[Category: Lim KW]] | |||
[[Category: Mechulam Y]] | |||
[[Category: Phan AT]] | |||
[[Category: Schmitt E]] | |||
Latest revision as of 11:19, 9 May 2024
Structure of a left-handed DNA G-quadruplex
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