3j9b: Difference between revisions

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'''Unreleased structure'''


The entry 3j9b is ON HOLD  until Paper Publication
==Electron cryo-microscopy of an RNA polymerase==
<SX load='3j9b' size='340' side='right' viewer='molstar' caption='[[3j9b]], [[Resolution|resolution]] 4.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3j9b]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1)) Influenza A virus (A/goose/Guangdong/1/1996(H5N1))], [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/goose/Guangdong/3/1997(H5N1)) Influenza A virus (A/goose/Guangdong/3/1997(H5N1))] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J9B FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j9b OCA], [https://pdbe.org/3j9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j9b RCSB], [https://www.ebi.ac.uk/pdbsum/3j9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j9b ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q91R78_9INFA Q91R78_9INFA] Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.[HAMAP-Rule:MF_04063]


Authors: Chang, S.H., Sun, D.P., Liang, H.H., Wang, J., Li, J., Guo, L., Wang, X.L., Guan, C.C., Boruah, B.M., Yuan, L.M., Feng, F., Yang, M.R., Wojdyla, J., Wang, J.W., Wang, M.T., Wang, H.W., Liu, Y.F.
==See Also==
 
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
Description: Electron cryo-microscopy of an RNA polymerase
__TOC__
[[Category: Unreleased Structures]]
</SX>
[[Category: Sun, D.P]]
[[Category: Large Structures]]
[[Category: Chang, S.H]]
[[Category: Synthetic construct]]
[[Category: Wang, M.T]]
[[Category: Boruah BM]]
[[Category: Wang, J.W]]
[[Category: Chang SH]]
[[Category: Yang, M.R]]
[[Category: Feng F]]
[[Category: Wojdyla, J]]
[[Category: Guan CC]]
[[Category: Li, J]]
[[Category: Guo L]]
[[Category: Wang, X.L]]
[[Category: Li J]]
[[Category: Liu, Y.F]]
[[Category: Liang HH]]
[[Category: Wang, H.W]]
[[Category: Liu YF]]
[[Category: Feng, F]]
[[Category: Sun DP]]
[[Category: Guo, L]]
[[Category: Wang HW]]
[[Category: Guan, C.C]]
[[Category: Wang J]]
[[Category: Boruah, B.M]]
[[Category: Wang JW]]
[[Category: Wang, J]]
[[Category: Wang MT]]
[[Category: Liang, H.H]]
[[Category: Wang XL]]
[[Category: Yuan, L.M]]
[[Category: Wojdyla J]]
[[Category: Yang MR]]
[[Category: Yuan LM]]
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