3j9b

Electron cryo-microscopy of an RNA polymerase

Loading... Status: waiting for Mol* initialization Structural highlights 3j9b is a 10 chain structure with sequence from Influenza A virus (A/goose/Guangdong/1/1996(H5N1)), Influenza A virus (A/goose/Guangdong/3/1997(H5N1)) and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 4.3Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q91R78_9INFA Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.[HAMAP-Rule:MF_04063] See Also RNA polymerase 3D structures

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