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| [[Image:3ffn.jpg|left|300px]]
| | <StructureSection load='1h1v' size='350' side='right' caption='Human gelsolin S4-S6 (gold) complex with actin (cyan), ATP and Ca+2 ion (green) (PDB entry [[1h1v]])' scene='41/410297/Cv/3'> |
| <!-- | | __TOC__ |
| {{Structure
| | == Function == |
| |PDB=3ffn|SIZE=350|SCENE=|CAPTION=Gelsolin (GLS), 3FFN
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| |SITE=
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| |LIGAND=
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| |ACTIVITY=
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| |GENE=
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| |DOMAIN=
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| |RELATEDENTRY=
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| |RESOURCES=
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| }}
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| -->
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| {{STRUCTURE_2fgh| PDB=2fgh | SCENE= |CAPTION=Gelsolin (GLS) dimer complex with ATP (red), [[2fgh]] }}
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| | [[Gelsolin]] (GLS) is a protein regulator of actin assembly and disassembly<ref>PMID:10559185</ref>. Binding of Ca+2 ion to GLS induces conformational change which enables it to bind actin. |
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| | == Structural highlights == |
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| | GLS contains 6 homologous domains S1 to S6. The human GLS domains span residues: 15-135, 136-248, 249-367, 394-513, 514-619 and 620-734. <scene name='41/410297/Cv/6'>S4-S6 are shown</scene>. The <scene name='41/410297/Cv/7'>binding site of Ca+2 ion includes Glu, Asp and 2 carbonyl oxygens</scene><ref>PMID:12460571</ref>. |
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| | == 3D Structures of gelsolin == |
| | [[Gelsolin 3D structures]] |
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| | </StructureSection> |
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| | | == References == |
| | | <references/> |
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| [[Gelsolin]] (GLS) is a protein regulator of actin assembly and disassembly. The image at the top left corresponds to the human gelsolin ([[3ffn]]), it has <scene name='Gelsolin/Cv/2'>dimeric form</scene>. It contains 6 homologous domains S1 to S6.
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| == 3D Structures of GLS == | |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| * GLS
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| **[[3ffn]] – hGLS – human <br />
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| **[[2fgh]] – hoGLS+ATP – horse <br />
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| **[[1d0n]] - hoGLS <br />
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| **[[2x1o]], [[2x1p]], [[2x1q]] – GLS nanobody - Llama
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| * GLS domains S1-S3
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| **[[3ffk]] – hGLS +actin <br />
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| **[[1rgi]] - hoGLS +actin <br />
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| * GLS domains S4-S6
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| **[[1h1v]] - hGLS +actin<br />
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| **[[1nph]] - GLS +Ca – mouse<br />
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| * GLS domain S1
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| **[[2ff3]] - hGLS +N-WASP+actin<br />
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| **[[2ff6]] - hGLS +Ciboulot domain 2+actin<br />
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| **[1mdu]] - hGLS +chActin – chicken<br />
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| **[[1d4x]] - hGLS +CeActin+Mg-ATP – ''Caenorhabditis elegans''<br />
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| **[[1esv]] - hGLS +rActin+latrunculin – rabbit<br />
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| **[[1eqy]] - hGLS +rActin<br />
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| **[[1yvn]] - hGLS +yActin (mutant) – yeast<br />
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| **[[1yag]] - hGLS +yActin<br />
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| **[[1t44]] - hGLS/thymosin β-4 C-terminal fusion+rActin<br />
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| **[[1kcq]] – hGLS +Cd<br />
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| **[[1c0f]], [[1mdu]], [[1nmd]] - hGLS + Actin+Ca-ATP <br />
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| **[[1c0g]], [[1dej]] - hGLS +Actin (mutant)<br />
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| **[[3a5l]], [[3a5m]], [[3a5n]], [[3a5o]] - hGLS (mutant)+Actin (mutant)<br />
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| **[[3ci5]], [[3cip]], [[1nlv]] – DdGLS +actin - ''Dictyostelium discoideum''<br />
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| **[[1nm1]] - DdGLS +actin+Mg-ATP<br />
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| **[[3cjb]] - rGLS +rActin<br />
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| **[[3cjc]] - rGLS +rActin+DNAse I<br />
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| **[[4cbu]], [[4cbw]], [[4cbx]] - mGLS +actin+Ca+ATP<br />
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| * GLS C-terminal
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| **[[2fh1]], [[2fh2]], [[2fh3]], [[2fh4]] – hGLS <br />
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| **[[1p8x]] - hGLS +Ca<br />
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| **[[1p8z]] – hGLS fraction+rActin<br />
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| }}
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |
