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| {{STRUCTURE_2x0c| PDB=2x0c | SIZE=400| SCENE=Talin/Cv/1 |right|CAPTION=Talin [[2x0c]] }}
| | <StructureSection load='' size='350' side='right' scene='Talin/Cv/1' caption='Talin rod domain residues 1359-1659 (PDB code [[2x0c]])'> |
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| [[Talin]] is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F0-F3. The F3 subdomains interacts with integrin. Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3.
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| | [[Talin]] is involved in cell-cell contacts. It links integrins to actin<ref>PMID:19416068</ref>. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F1-F3. The F3 subdomain interacts with integrin. Talin contains 3 [[Vinculin]] binding sites VBS1-VBS3. |
| | </StructureSection> |
| == 3D Structures of Talin == | | == 3D Structures of Talin == |
| | [[Talin 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | == References == |
| {{#tree:id=OrganizedByTopic|openlevels=0|
| | <references/> |
| | | </StructureSection> |
| * Talin subdomains
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| **[[2x0c]], [[2kbb]], [[3dyj]], [[1sj7]], [[1sj8]] – mTal rod – mouse<br />
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| **[[2kma]] – mTal F0F1 – NMR<br />
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| **[[2kc1]] - mTal F0 – NMR<br />
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| **[[2kc2]] - mTal F1 – NMR<br />
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| **[[2hrj]] - cTal F2 – NMR <br />
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| **[[1mix]] – cTal F2F3<br />
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| **[[4f7g]] - mTal F2F3 + rod segment domain<br />
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| **[[2kgx]] – mTal F3+mTal fragment – NMR<br />
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| **[[3ivf]] – mTal FERM domain<br />
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| **[[2l7n]] – mTal B – NMR<br />
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| **[[2l10]] – mTal C - NMR<br />
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| **[[2lqg]] - mTal R4 helix – NMR<br />
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| **[[4w8p]] - mTal R7-8 + RIAM <br />
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| **[[2mwn]] – hTal1 + RIAM – human - NMR<br />
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| * Talin integrin-binding sites
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| **[[2jsw]], [[2qdq]] – mTal IBS – NMR<br />
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| **[[3g9w]] – mTal2 F2F3+integrin tail<br />
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| **[[1miz]], [[1mk7]], [[1mk9]] - hTal+integrin tail<br />
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| **[[2h7d]], [[2h7e]] - cTal FERM F3+integrlin fragment – NMR <br />
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| **[[3fyq]] – Tal rod IBS2 – ''Drosophila melanogaster''
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| * Talin vinculin-binding sites
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| **[[2kvp]], [[2b0h]] – mTal VBS3 – NMR<br />
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| **[[1xwj]], [[1zvz]], [[1zw2]], [[1zw3]] - cTal VBS3+ vinculin head – chicken<br />
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| **[[1u6h]] - cTal VBS2+ vinculin head<br />
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| **[[1t01]] - cTal VBS1+ vinculin head<br />
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| **[[1syq]] - hTal VBS1+ vinculin head <br />
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| **[[1rkc]], [[3s90]] - hTal VBS3+ vinculin head<br />
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| **[[1u89]], [[2l7a]] - mTal VBS2 – NMR<br />
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| **[[4dj9]] – hTal VBS50 + vinculin head
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| *Talin phosphatidylinositol phosphate kinase binding sites
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| **[[1y19]] - mTal F2F3+ PIP kinase C-terminal<br />
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| **[[2g35]] - mTal F3+PIP kinase peptide – NMR
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| *Layilin binding sites
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| **[[2k00]] - cTal F3+layilin fragment – NMR
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| }}
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| [[Category: Topic Page]] | | [[Category: Topic Page]] |
