Symplekin: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='3o2s' size='340' side='right' caption='Human symplekin N terminal complex with RNA polymerase II subunit A C terminal phosphatase (PDB code 3o2s)' scene=''> ''... |
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<StructureSection load='3o2s' size='340' side='right' caption='Human symplekin N terminal (grey) complex with RNA polymerase II subunit A phosphatase C terminal (green) and phosphate ion (PDB code [[3o2s]])' scene=''> | |||
<StructureSection load='3o2s' size='340' side='right' caption='Human symplekin N terminal complex with RNA polymerase II subunit A C terminal | |||
== Function == | == Function == | ||
'''Symplekin''' (SMPK) is a scaffold protein recruiting regulatory factors to the multimolecular complex involved in histone mRNA 3’-end processing. SMPK is involved in pre-mRNA polyadenylation. It enhances the activity of RNA polymerase II subunit A C terminal phosphatase (Ssu72)<ref>PMID:8769423</ref>. | |||
== Relevance == | == Relevance == | ||
Overexpression of SMPK promotes tumorigenicity in the colon<ref>PMID20133805</ref>. | |||
</StructureSection> | </StructureSection> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[3o2t]], [[3odr]] – hSMPK N terminal – human <br /> | [[3o2t]], [[3odr]] – hSMPK N terminal – human <br /> | ||
[[3ods]] – hSMPK N terminal (mutant) <br /> | [[3ods]] – hSMPK N terminal (mutant) <br /> | ||
[[3o2s]] – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase<br /> | [[3o2s]] – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase<br /> | ||
[[4h3h]], [[3o2q]], [[4h3k]] – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase + phosphorylated peptide<br /> | [[4h3h]], [[3o2q]], [[4h3k]] – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase + phosphorylated peptide<br /> | ||
[[4imi]], [[4imj]] – DmSMPK | [[6v4x]] – hSMPK inhistone pre-mRNA 3’-end processing machinery – Cryo EM<br /> | ||
[[3gs3]] – DmSMPK N terminal – ''Drosophila melanogaster'' <br /> | |||
[[4imi]], [[4imj]], [[4ygx]], [[6npw]] – DmSMPK + SSU72 + phosphorylated peptide<br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||
