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==Arabidopsis Hexokinase 1 (AtHXK1) mutant S177A structure in glucose-bound form==
==Arabidopsis Hexokinase 1 (AtHXK1) mutant S177A structure in glucose-bound form==
<StructureSection load='4qs9' size='340' side='right' caption='[[4qs9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='4qs9' size='340' side='right'caption='[[4qs9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4qs9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QS9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QS9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4qs9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QS9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.103&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qs7|4qs7]], [[4qs8|4qs8]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qs9 OCA], [https://pdbe.org/4qs9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qs9 RCSB], [https://www.ebi.ac.uk/pdbsum/4qs9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qs9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qs9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qs9 RCSB], [http://www.ebi.ac.uk/pdbsum/4qs9 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HXK1_ARATH HXK1_ARATH]] Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells.<ref>PMID:12690200</ref> <ref>PMID:16920781</ref> <ref>PMID:9014361</ref>
[https://www.uniprot.org/uniprot/HXK1_ARATH HXK1_ARATH] Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells.<ref>PMID:12690200</ref> <ref>PMID:16920781</ref> <ref>PMID:9014361</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4qs9" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Hexokinase|Hexokinase]]
*[[Hexokinase 3D structures|Hexokinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hexokinase]]
[[Category: Arabidopsis thaliana]]
[[Category: Feng, J]]
[[Category: Large Structures]]
[[Category: Liu, L]]
[[Category: Feng J]]
[[Category: Zhao, S]]
[[Category: Liu L]]
[[Category: Atp-dependent]]
[[Category: Zhao S]]
[[Category: Sugar sensor]]
[[Category: Transferase]]

Latest revision as of 15:09, 8 November 2023

Arabidopsis Hexokinase 1 (AtHXK1) mutant S177A structure in glucose-bound form

4qs9, resolution 2.10Å

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