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==Crystal structure of E. coli undecaprenyl pyrophosphate synthase in complex with clomiphene==
==Crystal structure of E. coli undecaprenyl pyrophosphate synthase in complex with clomiphene==
<StructureSection load='5cqj' size='340' side='right' caption='[[5cqj]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='5cqj' size='340' side='right'caption='[[5cqj]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5cqj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CQJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[5cqj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CQJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=53Q:CLOMIFENE'>53Q</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cqb|5cqb]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=53Q:CLOMIFENE'>53Q</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ditrans,polycis-undecaprenyl-diphosphate_synthase_((2E,6E)-farnesyl-_diphosphate_specific) Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl- diphosphate specific)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.31 2.5.1.31] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cqj OCA], [https://pdbe.org/5cqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cqj RCSB], [https://www.ebi.ac.uk/pdbsum/5cqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cqj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cqj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5cqj RCSB], [http://www.ebi.ac.uk/pdbsum/5cqj PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/UPPS_ECOLI UPPS_ECOLI]] Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate (FPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.<ref>PMID:12756244</ref>
[https://www.uniprot.org/uniprot/UPPS_ECOLI UPPS_ECOLI] Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate (FPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.<ref>PMID:12756244</ref>  
 
==See Also==
*[[Undecaprenyl pyrophosphate synthase|Undecaprenyl pyrophosphate synthase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Conrady, D G]]
[[Category: Escherichia coli K-12]]
[[Category: Strynadka, N C]]
[[Category: Large Structures]]
[[Category: Worrall, L J]]
[[Category: Conrady DG]]
[[Category: Antibacterial]]
[[Category: Strynadka NC]]
[[Category: Cell wall]]
[[Category: Worrall LJ]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]
[[Category: Wall teichoic acid]]

Latest revision as of 12:21, 6 March 2024

Crystal structure of E. coli undecaprenyl pyrophosphate synthase in complex with clomiphene

5cqj, resolution 2.15Å

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