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==Crystal Structure of Norwalk Virus Polymerase (MgSO4 crystal form)==
==Crystal Structure of Norwalk Virus Polymerase (MgSO4 crystal form)==
<StructureSection load='1sh3' size='340' side='right' caption='[[1sh3]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
<StructureSection load='1sh3' size='340' side='right'caption='[[1sh3]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1sh3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Norwalk_calicivirus Norwalk calicivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SH3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1sh3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norwalk_virus Norwalk virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SH3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1khv|1khv]], [[1sh0|1sh0]], [[1sh2|1sh2]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh3 OCA], [https://pdbe.org/1sh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sh3 RCSB], [https://www.ebi.ac.uk/pdbsum/1sh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sh3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sh3 OCA], [http://pdbe.org/1sh3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sh3 RCSB], [http://www.ebi.ac.uk/pdbsum/1sh3 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q70ET3_9CALI Q70ET3_9CALI]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sh/1sh3_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sh/1sh3_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sh3 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
*[[RNA polymerase|RNA polymerase]]
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Norwalk calicivirus]]
[[Category: Large Structures]]
[[Category: RNA-directed RNA polymerase]]
[[Category: Norwalk virus]]
[[Category: Alonso, J M]]
[[Category: Alonso JM]]
[[Category: Boga, J A]]
[[Category: Boga JA]]
[[Category: Machin, A]]
[[Category: Machin A]]
[[Category: Ng, K K]]
[[Category: Ng KK]]
[[Category: Parra, F]]
[[Category: Parra F]]
[[Category: Pendas-Franco, N]]
[[Category: Pendas-Franco N]]
[[Category: Rojo, J]]
[[Category: Rojo J]]
[[Category: Rna polymerase]]
[[Category: Transferase]]
[[Category: Viral replication enzyme]]

Latest revision as of 06:16, 23 August 2023

Crystal Structure of Norwalk Virus Polymerase (MgSO4 crystal form)

1sh3, resolution 2.95Å

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