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[[Image:2hxp.gif|left|200px]]


{{Structure
==Crystal Structure of the human phosphatase (DUSP9)==
|PDB= 2hxp |SIZE=350|CAPTION= <scene name='initialview01'>2hxp</scene>, resolution 1.83&Aring;
<StructureSection load='2hxp' size='340' side='right'caption='[[2hxp]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
<table><tr><td colspan='2'>[[2hxp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HXP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HXP FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
|GENE= DUSP9, MKP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00127 DSPc]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hxp OCA], [https://pdbe.org/2hxp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hxp RCSB], [https://www.ebi.ac.uk/pdbsum/2hxp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hxp ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2hxp TOPSAN]</span></td></tr>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hxp OCA], [http://www.ebi.ac.uk/pdbsum/2hxp PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2hxp RCSB]</span>
</table>
}}
== Function ==
[https://www.uniprot.org/uniprot/DUS9_HUMAN DUS9_HUMAN] Inactivates MAP kinases. Has a specificity for the ERK family.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hx/2hxp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hxp ConSurf].
<div style="clear:both"></div>


'''Crystal Structure of the human phosphatase (DUSP9)'''
==See Also==
 
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2HXP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HXP OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Burley SK]]
[[Category: Burley, S K.]]
[[Category: Eswaramoorthy S]]
[[Category: Eswaramoorthy, S.]]
[[Category: Madegowda M]]
[[Category: Madegowda, M.]]
[[Category: Swaminathan S]]
[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: Swaminathan, S.]]
[[Category: 8638a]]
[[Category: human phosphatase]]
[[Category: new york structural genomix research consortium]]
[[Category: nysgxrc]]
[[Category: protein structure initiative]]
[[Category: psi-2]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:30:08 2008''

Latest revision as of 09:35, 14 February 2024

Crystal Structure of the human phosphatase (DUSP9)

2hxp, resolution 1.83Å

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