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| <StructureSection load='2nxy' size='450' side='right' caption='Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry [[2nxy]])' scene='55/551234/Cv/1'> | | <StructureSection load='2nxy' size='350' side='right' caption='Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry [[2nxy]])' scene='55/551234/Cv/1'> |
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| '''CD4''' (or '''Cluster of Differentiation 4''') is a glycoprotein found on the surface of immune cells. CD4 has 4 immunoglobulin (Ig) domains (D1-D4), a transmembrane domain and a cytoplasmic tail domain. D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain. The D1 domain interacts with class II MHC molecules. CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells. The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway. HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.<ref>PMID:8493535</ref>
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| *<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>
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| </StructureSection>
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| ==3D structures of CD4==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | == Function == |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| | '''CD4''' (or '''Cluster of Differentiation 4''' or '''T cell surface glycoprotein CD4''') is a glycoprotein found on the surface of immune cells. CD4 has 4 immunoglobulin (Ig) domains (D1-D4), a transmembrane domain and a cytoplasmic tail domain. D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain. The D1 domain interacts with class II MHC molecules. CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells. The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway. |
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| *CD4 domains
| | == Relevance == |
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| **[[1cid]] – rCD4 D3 and D4 domains - rat<BR />
| | HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.<ref>PMID:8493535</ref> |
| **[[3cd4]], [[1cdh]], [[1cdi]], [[1cdj]] – hCD4 D1 and D2 domains - human<BR /> | | *<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref> |
| **[[1cdu]], [[1cdy]] – hCD4 D1 and D2 domains (mutant)<BR />
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| **[[1wio]], [[1wip]], [[1wiq]] – hCD4 D1, D2, D3 and D4 domains <BR />
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| **[[2klu]] – hCD4 transmembrane and tail domains - NMR<BR />
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| *CD4 binary complex
| | ==3D structures of CD4== |
| | [[CD4 3D structures]] |
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| **[[1q68]] – hCD4 tail + Lck peptide - NMR<BR />
| | </StructureSection> |
| **[[3b71]] – hCD4 tail + focal adhesion kinase 1<BR />
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| **[[3o2d]] – hCD4 D1 and D2 domains + antibody <BR />
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| *CD4 ternary complex
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| **[[1gc1]], [[1g9m]], [[1g9n]], [[1rzj]], [[1rzk]], [[2b4c]], [[2nxy]], [[2nxz]], [[2ny0]], [[2ny1]], [[2ny2]], [[2ny3]], [[2ny4]], [[2ny5]], [[2ny6]], [[3jwd]], [[3jwo]], [[4jm2]] – hCD4 D1 and D2 domains + antibody + gp120<BR />
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| **[[2qad]], [[3lqa]] – hCD4 D1 and D2 domains + antibody + gp160<BR />
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| **[[1jl4]] – hCD4 D1 and D2 domains + class II MHC + ovotransferin peptide<BR />
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| **[[3s4s]] – hCD4 D1 and D2 domains + class II MHC + haemaglutinin peptide<BR />
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| **[[3s5l]] – hCD4 D1 and D2 domains + class II MHC + HA peptide<BR />
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| **[[3t0e]] – hCD4 D1 and D2 domains + class II MHC + TCR<BR />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category: Topic Page]] | | [[Category: Topic Page]] |
