CD4: Difference between revisions

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<StructureSection load='2nxy' size='450' side='right' caption='Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry [[2nxy]])' scene='55/551234/Cv/1'>
<StructureSection load='2nxy' size='350' side='right' caption='Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry [[2nxy]])' scene='55/551234/Cv/1'>
 
 
== Function ==
== Function ==
      
      
'''CD4''' (or '''Cluster of Differentiation 4''') is a glycoprotein found on the surface of immune cells.  CD4 has 4 immunoglobulin (Ig) domains (D1-D4), a transmembrane domain and a cytoplasmic tail domain.  D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain.  The D1 domain interacts with class II MHC molecules.  CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells.  The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway.   
'''CD4''' (or '''Cluster of Differentiation 4''' or '''T cell surface glycoprotein CD4''') is a glycoprotein found on the surface of immune cells.  CD4 has 4 immunoglobulin (Ig) domains (D1-D4), a transmembrane domain and a cytoplasmic tail domain.  D1 and D3 resemble Ig variable domain and D2 and D4 resemble the Ig constant domain.  The D1 domain interacts with class II MHC molecules.  CD4 helps T-cell receptors (TCR) interact with antigen-presenting cells.  The CD4 tail interacts with tyrosine kinase Lck which activates molecular components of the signaling pathway.   


== Relevance ==
== Relevance ==
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HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.<ref>PMID:8493535</ref>
HIV-1 binds to CD4 initiating conformation changes in its protein gp120 and allowing the entry of HIV-1 to the host T-cell.<ref>PMID:8493535</ref>
*<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>
*<scene name='55/551234/Cv/2'>CD4 with antibody and HIV-1 gp120</scene> ([[2nxy]]).<ref>PMID:17301785</ref>
</StructureSection>


==3D structures of CD4==
==3D structures of CD4==
[[CD4 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*CD4 domains
 
**[[1cid]] – rCD4 D3 and D4 domains - rat<BR />
**[[3cd4]], [[1cdh]], [[1cdi]], [[1cdj]] – hCD4 D1 and D2 domains - human<BR />
**[[1cdu]], [[1cdy]] – hCD4 D1 and D2 domains (mutant)<BR />
**[[1wio]], [[1wip]], [[1wiq]] – hCD4 D1, D2, D3 and D4 domains <BR />
**[[2klu]] – hCD4 transmembrane and tail domains - NMR<BR />
 
*CD4 binary complex
 
**[[1q68]] – hCD4 tail + Lck peptide - NMR<BR />
**[[3b71]] – hCD4 tail + focal adhesion kinase 1<BR />
**[[3o2d]] – hCD4 D1 and D2 domains + antibody <BR />
 
*CD4 ternary complex


**[[1gc1]], [[1g9m]], [[1g9n]], [[1rzj]], [[1rzk]], [[2b4c]], [[2nxy]], [[2nxz]], [[2ny0]], [[2ny1]], [[2ny2]], [[2ny3]], [[2ny4]], [[2ny5]], [[2ny6]], [[3jwd]], [[3jwo]], [[4jm2]] – hCD4 D1 and D2 domains + antibody + gp120<BR />
**[[2qad]], [[3lqa]] – hCD4 D1 and D2 domains + antibody + gp160<BR />
**[[1jl4]] – hCD4 D1 and D2 domains + class II MHC + ovotransferin peptide<BR />
**[[3s4s]] – hCD4 D1 and D2 domains + class II MHC + haemaglutinin peptide<BR />
**[[3s5l]] – hCD4 D1 and D2 domains + class II MHC + HA peptide<BR />
**[[3t0e]] – hCD4 D1 and D2 domains + class II MHC + TCR<BR />
}}
== References ==
== References ==
<references/>
<references/>
[[Category: Topic Page]]
[[Category: Topic Page]]

Latest revision as of 08:57, 1 May 2019

Structure of CD4 (green) complex with antibody light chain (pink), heavy chain (yellow), HIV-1 gp120 (cyan), TRIS and hexane-diol (PDB entry 2nxy)

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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