Concanavalin: Difference between revisions

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<StructureSection load='1qdc' size='350' side='right' caption='Concanavalin A complex with trisacchride, Mn+2 (small purple), Cl- (large green) and Ca+2 (small green) ions (large purple) (PDB entry [[1qdc]])' scene=''>
<StructureSection load='1qdc' size='350' side='right' caption='Concanavalin A complex with trisacchride, Mn+2 (small purple), Cl- (large green) and Ca+2 (small green) ions (large purple) (PDB entry [[1qdc]])' scene='41/415806/Cv/1'>
__TOC__
== Function ==


'''Concanavalin A''' (ConA) is a carbohydrate-binding protein from jack-bean (''Canavalia ensiformis'').  It binds to certain sugars and to metal.  It is used to characterize glycoproteins on cell surfaces.
'''Concanavalin A''' (ConA) is a carbohydrate-binding protein from jack-bean (''Canavalia ensiformis'').  It binds to certain sugars and to metal.  It is used to characterize glycoproteins on cell surfaces.<ref>PMID:9546043</ref>. 
</StructureSection>
*'''Concanavalin B''' (ConB) is related to chitinase with 40% sequence identity.<ref>PMID:7490746</ref>. 
== 3D Structures of Concanavalin A ==
*'''Concanavalin BR''' (ConBR) is ConA from Brazilian jack bean.
*'''Concanavalin V''' (ConV) is a D-mannose/D-glucose-binding lectin.
 
== Relevance ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
ConA has therapeutic effect on liver cancer.
{{#tree:id=OrganizedByTopic|openlevels=0|


*Concanavalin A
== Structural highlights ==


**[[2uu8]], [[1nxd]], [[1gkb]], [[3enr]], [[1qny]], [[1vln]], [[1jbc]], [[1cnv]], [[2cna]], [[3cna]], [[3nwk]] – CeConA – ''Canavalia ensiformis''<br />
ConA is the <scene name='41/415806/Cv/2'>homotetramer</scene> with D2 symmetry. ConA contains a <scene name='41/415806/Cv/7'>metal - Mn+2 and Ca+2 - binding site</scene> as well as a <scene name='41/415806/Cv/8'>sugar binding site</scene>.
**[[2yz4]], [[1xqn]], [[1c57]] – CeConA – neutron<br />
**[[2ctv]] – CeConA – Laue<br />
**[[1cn1]], [[1apn]], [[1dq0]], [[1dq2]] – CeConA demetallized<br />
**[[2g4i]], [[2a7a]] – ConA – ''Canavalia virosa''<br />
**[[1wuv]] – CgConA – ''Canavalia gladiata''<br />
**[[3ju9]], [[1azd]] – BrConBR – Brazilian jack-bean<br />
**[[2cwm]] - CmConA – ''Canavalia maritima''


*Concanavalin binary complex
== 3D Structures of Concanavalin ==
[[Concanavalin 3D structures]]


**[[1dq1]], [[1dq5]], [[1dq6]], [[1qgl]], [[1nls]], [[1scr]], [[1scs]] – CeConA + ion<br />
</StructureSection>
**[[1enq]], [[1enr]], [[1ens]], [[1con]], [[1dq4]], [[2enr]], [[1ces]] - CeConA demetallized + ion<br />
**[[3d4k]] – CeConA + sugar analog<br />
**[[1hqw]], [[1jyc]], [[1jyi]], [[1jui]], [[1joj]], [[1jw6]] – CeConA + polypeptide<br />
**[[1jn2]] – CeConA + porphyrin derivative<br />
**[[1cjp]], [[1ona]], [[1gic]], [[1val]], [[1vam]], [[5cna]], [[4p9x]], [[4p9w]], [[4p9y]], [[4pf5]] – CeConA + pyranoside derivative<br />
**[[1i3h]], [[1qdc]], [[1qdo]], [[1bxh]], [[1tei]], [[1cvn]] – CeConA + glucoside<br />
**[[2p37]], [[2cy6]], [[2cyf]], [[2ow4]], [[2p34]] – CmConA + glucoside <br />
**[[2ef6]], [[2d7f]], [[2ovu]], [[2p2k]] - CgConA + glucoside<br />
**[[3qlq]] - ConA + glucosyl-octasilsesquioxane – ''Canavalia cathartica''<br />
**[[3snm]] - ClConA + indole-acetate – ''Canavalia lineata''<br />
**[[4i30]] – ClConA + adenine<br />
**[[4h55]] - BrConA + glucoside<br />
**[[4dpn]] – ClConA + resveratrol<br />


}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 08:22, 6 February 2025

Concanavalin A complex with trisacchride, Mn+2 (small purple), Cl- (large green) and Ca+2 (small green) ions (large purple) (PDB entry 1qdc)

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References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Eran Hodis, Jaime Prilusky

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