Concanavalin: Difference between revisions

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== Function ==
== Function ==


'''Concanavalin A''' (ConA) is a carbohydrate-binding protein from jack-bean (''Canavalia ensiformis'').  It binds to certain sugars and to metal.  It is used to characterize glycoproteins on cell surfaces.<ref>PMID:9546043</ref>
'''Concanavalin A''' (ConA) is a carbohydrate-binding protein from jack-bean (''Canavalia ensiformis'').  It binds to certain sugars and to metal.  It is used to characterize glycoproteins on cell surfaces.<ref>PMID:9546043</ref>. 
*'''Concanavalin B''' (ConB) is related to chitinase with 40% sequence identity.<ref>PMID:7490746</ref>. 
*'''Concanavalin BR''' (ConBR) is ConA from Brazilian jack bean.
*'''Concanavalin V''' (ConV) is a D-mannose/D-glucose-binding lectin.


== Relevance ==
== Relevance ==
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== Structural highlights ==
== Structural highlights ==


ConA is the<scene name='41/415806/Cv/2'>homotetramer</scene> with D2 symmetry. ConA contains a <scene name='41/415806/Cv/3'>metal - Mn+2 and Ca+2 - binding site</scene> as well as a sugar binding site.
ConA is the <scene name='41/415806/Cv/2'>homotetramer</scene> with D2 symmetry. ConA contains a <scene name='41/415806/Cv/7'>metal - Mn+2 and Ca+2 - binding site</scene> as well as a <scene name='41/415806/Cv/8'>sugar binding site</scene>.
</StructureSection>
== 3D Structures of Concanavalin A ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
== 3D Structures of Concanavalin ==
{{#tree:id=OrganizedByTopic|openlevels=0|
[[Concanavalin 3D structures]]


*Concanavalin A
</StructureSection>
 
**[[2uu8]], [[1nxd]], [[1gkb]], [[3enr]], [[1qny]], [[1vln]], [[1jbc]], [[1cnv]], [[2cna]], [[3cna]], [[3nwk]] – CeConA – ''Canavalia ensiformis''<br />
**[[2yz4]], [[1xqn]], [[1c57]] – CeConA – neutron<br />
**[[2ctv]] – CeConA – Laue<br />
**[[1cn1]], [[1apn]], [[1dq0]], [[1dq2]] – CeConA demetallized<br />
**[[2g4i]], [[2a7a]] – ConA – ''Canavalia virosa''<br />
**[[1wuv]] – CgConA – ''Canavalia gladiata''<br />
**[[3ju9]], [[1azd]] – BrConBR – Brazilian jack-bean<br />
**[[2cwm]] - CmConA – ''Canavalia maritima''
 
*Concanavalin binary complex
 
**[[1dq1]], [[1dq5]], [[1dq6]], [[1qgl]], [[1nls]], [[1scr]], [[1scs]] – CeConA + ion<br />
**[[1enq]], [[1enr]], [[1ens]], [[1con]], [[1dq4]], [[2enr]], [[1ces]] - CeConA demetallized + ion<br />
**[[3d4k]] – CeConA + sugar analog<br />
**[[1hqw]], [[1jyc]], [[1jyi]], [[1jui]], [[1joj]], [[1jw6]] – CeConA + polypeptide<br />
**[[1jn2]] – CeConA + porphyrin derivative<br />
**[[1cjp]], [[1ona]], [[1gic]], [[1val]], [[1vam]], [[5cna]], [[4p9x]], [[4p9w]], [[4p9y]], [[4pf5]] – CeConA + pyranoside derivative<br />
**[[1i3h]], [[1qdc]], [[1qdo]], [[1bxh]], [[1tei]], [[1cvn]] – CeConA + glucoside<br />
**[[2p37]], [[2cy6]], [[2cyf]], [[2ow4]], [[2p34]] – CmConA + glucoside <br />
**[[2ef6]], [[2d7f]], [[2ovu]], [[2p2k]] - CgConA + glucoside<br />
**[[3qlq]] - ConA + glucosyl-octasilsesquioxane – ''Canavalia cathartica''<br />
**[[3snm]] - ClConA + indole-acetate – ''Canavalia lineata''<br />
**[[4i30]] – ClConA + adenine<br />
**[[4h55]] - BrConA + glucoside<br />
**[[4dpn]] – ClConA + resveratrol<br />


}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
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