5hjs: Difference between revisions
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==Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease== | |||
<StructureSection load='5hjs' size='340' side='right'caption='[[5hjs]], [[Resolution|resolution]] 1.72Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5hjs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HJS FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=668:2-CHLORO-4-{1-[(2R)-2-HYDROXY-3-METHYL-2-(TRIFLUOROMETHYL)BUTANOYL]-4,4-BIPIPERIDIN-1-YL}-N,N-DIMETHYLBENZAMIDE'>668</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hjs OCA], [https://pdbe.org/5hjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hjs RCSB], [https://www.ebi.ac.uk/pdbsum/5hjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hjs ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NR1H3_HUMAN NR1H3_HUMAN] Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity). | |||
==See Also== | |||
*[[Liver X receptor|Liver X receptor]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Klein D]] | |||
[[Category: Parthasarathy G]] | |||
Latest revision as of 12:32, 6 March 2024
Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease
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