Factor VIII: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
Michal Harel (talk | contribs)
32,831 edits
No edit summary
Michal Harel (talk | contribs)
32,831 edits
No edit summary
 
(11 intermediate revisions by 2 users not shown)
Line 1: Line 1:
 
<StructureSection load='2r7e' size='350' side='right' scene='45/451726/Cv/2' caption='Glycosylated human Factor VIII.  Residues 19-760 (cyan), 1582-2351 (magenta) complex with Ca+2 (green) and Cu+2 (orange) ions (PDB code [[2r7e]]) '>
<StructureSection load='2r7e' size='350' side='right' scene='' caption='Glycosylated human Factor VIII.  Residues 19-760 (grey) 1582-2351 (green) complex with Ca+2 (green) and Cu+2 (orange) ions (PDB code [[2r7e]]) '>
== Function ==
== Function ==


[[Factor VIII]] (FVIII) is a blood clotting factor.  FVIII is a cofactor for [[Factor IX|factor IXa]]<ref>PMID:2491949</ref> . See also [[Factor VIII (Hebrew)]].
[[Factor VIII]] (FVIII) is a blood clotting factor.  FVIII is a cofactor for [[Factor IX|factor IXa]]<ref>PMID:2491949</ref> . See also [[Factor VIII (Hebrew)]].


<!--
<scene name='45/451726/Cv/7'>First Ca coordination site</scene>.
===RECOMBINANT HUMAN CELLULAR COAGULATION FACTOR XIII===
 
The A subunit is composed of an activation peptide and 4 domains: the β-sandwich <scene name='1f13/Chaina_domain1/1'>domain</scene>, the central core domain, the barrel 1 domain, and the
<scene name='45/451726/Cv/8'>Second Ca coordination site</scene>.
<scene name='1f13/Fxiii_4domains_colored/1'>barrel 2 domain</scene>.-->
 
<scene name='45/451726/Cv/9'>First Cu coordination site</scene>.
 
<scene name='45/451726/Cv/10'>Second Cu coordination site</scene> (PDB code [[2r7e]]).<ref>PMID:17965321</ref>
== Disease ==
== Disease ==


Defects in the protein result in hemophilia A.
Defects in the protein result in [[Hemophilia|hemophilia]] A.


== Relevance ==
== Relevance ==
Line 26: Line 28:
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}


[[2r7e]], [[3cdz]], [[3j2q]], [[4bdv]] – hFVIII – human<br />
[[2r7e]], [[3cdz]], [[3j2q]], [[4bdv]], [[6mf2]] – hFVIII 19-760+1582-2351 – human<br />
[[3hnb]], [[3hny]], [[3hob]] – hFVIII light chain C2 domain<br />
[[6mf0]] – h/pFVIII<br />
[[3hnb]], [[3hny]], [[3hob]], [[4pt6]] – hFVIII light chain C2 domain 2189-2347<br />
[[1d7p]] - hFVIII light chain C2 domain (mutant)<br />
[[1d7p]] - hFVIII light chain C2 domain (mutant)<br />
[[1cfg]], [[1fac]] - hFVIII light chain C2 domain membrane-binding peptide - NMR<br />
[[1cfg]], [[1fac]] - hFVIII light chain C2 domain membrane-binding peptide - NMR<br />
[[1iqd]] - hFVIII light chain C2 domain (mutant) + monoclonal Fab<br />
[[7k66]], [[7kbt]] – h/pFVIII + antibody<br />
[[4xzu]] - hFVIII light chain C2 domain + monoclonal Fab <br />
[[1iqd]] - hFVIII light chain C2 domain (mutant) + monoclonal Fab<br />
[[3j2s]] - hFVIII light chain 1710-2356<br />
[[5k8d]] - hFVIII heavy chain + light chain residues 104-329<br />
[[7kwo]] – hFVIII + VWF-XTEN<br />
[[4mo3]] - pFVIII light chain C2 domain – pig<br />
[[7s0p]] - pFVIII light chain C2 domain + phosphatidylserine<br />
[[4ki5]] - mFVIII light chain C2 domain + monoclonal Fab – mouse<br />
[[4ki5]] - mFVIII light chain C2 domain + monoclonal Fab – mouse<br />
[[3j2s]] - hFVIII light chain<br />
== References ==
[[4mo3]] - FVIII light chain C2 domain – pig<br />
<references/>
 


[[Category:Topic Page]]
[[Category:Topic Page]]
Retrieved from "https://proteopedia.org/Factor_VIII"